DING Jie, WANG Ai-xia, NIU Ben, et al. Optimization of Matrix Formulation of Artemisia Flavonoids Cream by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(7): 49-52.
DOI:
DING Jie, WANG Ai-xia, NIU Ben, et al. Optimization of Matrix Formulation of Artemisia Flavonoids Cream by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(7): 49-52. DOI: 10.11653/zgsyfjxzz2013070049.
Optimization of Matrix Formulation of Artemisia Flavonoids Cream by Orthogonal Test
Objective: To optimize matrix composition and ratio of artemisia flavonoids cream. Method: L9(34) orthogonal test was employed to investigate effects of four factors including the amount of cetyl alcohol
octadecanol
emulsifiers
1
3-propylene glycol on matrix formulation
with appearance
stability
ductility
viscosity
pH value and microscopic observation as comprehensive evaluation index. Result: The best proportion of matrix prescription was as following:artemisia flavonoids 0.5%
cetyl alcohol 6%
octadecano 6%
emulsifier 8%
1
3-propylene glycol 4%
urea 2%
pure water 64%. Conclusion: This prepared cream was fine and uniform with suitable consistence and ductility
stable properties.The color of it was bright yellow
odor was special smell of traditional Chinese medicine
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