Objective: To study the effect of Epimedii Folium on ovariectomy-induced osteoporosis in rats. Method: The female SD rats were divided into sham operated group(Sham)

ovariectomized group(Model)

high concentration Epimedii Folium with ovariectomized group(H-EF) and low concentration Epimedii Folium with ovariectomized group(L-EF).The serum Ca2+ were examined after administration for 45 days and 90 days. And the serum P

superoxide dismutase(SOD)

malonaldehyde(MDA)

estradiol(E2)

testosterone(T)and alkaline phosphatase (ALP) were examined after 90 days ofadministration. The tibial slice was also analysized. Result: Compared with the model group

the serum Ca2+ was decreased [(2.48±0.39)mmol·L-1(P<0.05)

(2.86±0.34)mmol·L-1(P<0.01)] by epimedium after 45 days of administration

and the serum MDA (8.4±1.3)mmol·L-1(P<0.01)for 90 days. But the serum ALP(4.4±0.89)U·L-1(P<0.05)

P(4.61±0.82)mmol·L-1(P<0.05)

E2(25.66±9.38) pg·L-1(P<0.05)

T(1.95±1.21) ng·L-1(P<0.05) and SOD (110±13)U·L-1(P<0.05) were all increased by high concentration Epimedii Folium. Conclusion: It may be one of the mechanisms on osteoporosis that Epimedii Folium enhance estrogen and decrease ROS.