Objective: To explore the effect of the compalibility of glycyrrhizic acid and aconitine on nerve cell. Method: Neuron cells were prepared from neonatal SD rats and cultured in vitro. The MTT assay was used to determine how mixture of the glycyrrhizic acid and aconitine in different proportions infect the survival of nerve cell. Then the activity of Na+

K+-ATPase and the contents of [Na+]

[K+] in the cells were measured using colorimetric method. Result: The activity of Na+

K+-ATPase and the contents of [Na+] in the cells were increased

while the contents of [K+] in the cells and the survival rate of nerve cell were decreased

after administration by the 2 g·L-1 aconitine for 30 min. The mixture of glycyrrhizic acid and aconitine in different proportions could lighten those changes caused by aconitine. Conclusion: Glycyrrhizic acid probably can decrease the toxicity of aconitine and antagonise the disturbance of internal environment in nerve cells. Besides

the best compatibility proportion is 1:2.