JIANG Ming-jin, ZHOU Ji-yin, ZENG Sheng-ya, et al. Effects of Ethanolic Extract of Roots on Glucolipid Metabolization in Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(7): 217-220.
DOI:
JIANG Ming-jin, ZHOU Ji-yin, ZENG Sheng-ya, et al. Effects of Ethanolic Extract of Roots on Glucolipid Metabolization in Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(7): 217-220. DOI: 10.11653/zgsyfjxzz2013070217.
Effects of Ethanolic Extract of Roots on Glucolipid Metabolization in Diabetic Rats
Objective: To investigate the effects of ethanolic extract of Mirabilis jalapa L. roots on glucolipid metabolization in diabetic rats. Method: Type 2 diabetes mellitus rats were induced by intraperitoneal injection 40 mg·kg-1 streptozotocin and a high-carbohydrate/high-fat diet. Rats were divided into following groups: normal group
model group
ethanolic extract of M. jalapa roots group (1
2
4 g·kg-1) and rosiglitazone group(4 mg·kg-1). After 8-weeks treatment
fasting blood glucose(FBG)
hemoglobin(HbAlC)
total cholesterol(TC)
triglyceride(TG)
serum insulin (FINS) levels and glycogen contents in liver and skeletal muscle were assayed. Result: Compared with the normal group
FBG
HbAlC
TC
TG
FINS levels were significantly increased
and insulin sensitivity index(ISI)
glycogen contents in liver and skeletal muscle decreased significantly in the model group (P<0.01). Compared with the model group
the levels of FBG
HbAlC
TC
TG
FINS decreased significantly
and ISI
glycogen contents in liver and skeletal muscle increased significantly in the ethanolic extract of M. jalapa roots group(2
4 g·kg-1)(P<0.01). Conclusion: ethanolic extract of M. jalapa roots possesses both potential hypoglycemic and hypolipidemic effects on diabetes.