YUE Yuan, DOU Li-li, CHANG Rui-miao, et al. Effects of Yixinnao Dripping Pills on Platelet Aggregation and Thrombus Formation and Coagulability Activity[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(7): 241-244.
DOI:
YUE Yuan, DOU Li-li, CHANG Rui-miao, et al. Effects of Yixinnao Dripping Pills on Platelet Aggregation and Thrombus Formation and Coagulability Activity[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(7): 241-244. DOI: 10.11653/zgsyfjxzz2013070241.
Effects of Yixinnao Dripping Pills on Platelet Aggregation and Thrombus Formation and Coagulability Activity
Objective: To investigate the effects of Yixinnao dripping pills on platelet aggregation and thrombus formation in rats
as well as the effects on coagulability activity. Method: The Wistar rats were divided into normal control group
aspirin group
Yixinnao dripping pills high
middle and low dose group(906
453
226 mg·kg-1
ig
accordingly). The effects of Yixinnao dripping pills on platelet aggregation in vivo were measured by the model induced by ADP
thrombin and CaCl2.Coagulation time in acute blood stasis rat models was determined by the glass capillary method and the effects were also evaluated on prothrombin time (PT) and thrombin time (TT) in these groups. The inhibitory action of Yixinnao dripping pills on the thrombus formation was investigated by the model of artery-vein bypass thrombosis. Result: Yixinnao dripping pills in the high
middle and low dose could signifiinhibit platelet aggregation induced by ADP
thrombin and CaCl2
respectly (P<0.05 or P<0.01). It could also lengthen coagulation time
TT and PT in different degree (P<0.05 or P<0.01).Moreover
Yixinnao dripping pills (906
453 mg·kg-1) could markedly restrain thrombus formation
reduce thrombus weight (P<0.05 or P<0.01). Conclusion: Yixinnao dripping pills showed the function of anti-thrombosis
and exerted the effects on inhibition of platelet aggregation and coagulability.