LIANG Wan-nian, JIANG Tao, CHEN Yan-fen, et al. Effect of Total Flavonoids from on Visceral Hypersensitivity in Rat Model with Irritable Bowel Syndrome and Analgesic Effects[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(7): 263-267.
DOI:
LIANG Wan-nian, JIANG Tao, CHEN Yan-fen, et al. Effect of Total Flavonoids from on Visceral Hypersensitivity in Rat Model with Irritable Bowel Syndrome and Analgesic Effects[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(7): 263-267. DOI: 10.11653/zgsyfjxzz2013070263.
Effect of Total Flavonoids from on Visceral Hypersensitivity in Rat Model with Irritable Bowel Syndrome and Analgesic Effects
Objective: To study the therapeutic effect in visceral hypersensitivity rat model with irritable bowel syndrome (IBS) induced by acetic acid and analgesic effect of total flavonoids from Alpinia officinarum(GLJ) and supply experimental evidence to the therapy of irritable bowel syndrome. Method: IBS models in SD rats were established by acetic acid for 2 weeks
and then the rats were randomized into model group
pinaverium group
GLJ high dose group
GLJ middle dose group
and GLJ low dose group. After treatment for 2 weeks
the therapeutic effect of GLJ was assessed by observing the abdominal withdrawal reflex (AWR) condition. The analgesic effects of GLJ were observed in pain models of mice induced by hot plate
acetic acid
pressure and formalin. Result: GLJ could effectively reduce the sensitivity of visceral hypersensitivity rat model of IBS induced by acetic acid(P<0.01 or P<0.05) and had analgesic effect on the pain models of hot plate
acetic acid and formalin (P<0.01 or P<0.05). Conclusion: GLJ has better therapeutic effect on visceral hypersensitivity rat model of IBS and analgesic effect.
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