ZHAO Wen-hong, HU Shu-bin, ZHANG Guo-ying, et al. Effect of Traditional Chinese Medicine Therapy on t-PA,PAI-1 to Chronic Renal Failure Patients[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(7): 297-299.
DOI:
ZHAO Wen-hong, HU Shu-bin, ZHANG Guo-ying, et al. Effect of Traditional Chinese Medicine Therapy on t-PA,PAI-1 to Chronic Renal Failure Patients[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(7): 297-299. DOI: 10.11653/zgsyfjxzz2013070297.
Effect of Traditional Chinese Medicine Therapy on t-PA,PAI-1 to Chronic Renal Failure Patients
Objective: To investigate the effects of traditional Chinese(TCM) medicine therapy on plasminogen activator(t-PA)
plasminogen activator inhibitor(PAI-1) to chronic renal failure(CFR) patients and its intervention way. Method: The patients of chronic kidney disease(CKD) 4 were randomly divided into 4 groups: western medicine group
western medicine with herbs group
western medicine with herbs and clysis group
and western medicine with herbs
clysis and fumigation group
and treated with the medicine respectively.In the third month
serum creatinine
blood urea nitrogen
plasma t-PA and PAI-1 were detected before and after treatment. Result: In TCM treatments
the levels of plasma PAI-1 were decreased
renal function was improved
and the levels of plasma t-PA were increased significantly as compared to western medicine group(P<0.05).The 4th group decreased the levels of serum creatinine
blood urea nitrogen and increased the levels of plasma t-PA bestly(P<0.05)
but there were no significant differences among the three groups about the decreasing of plasma PAI-1. Conclusion: TCM treatments could intervent CRF by modulating the activity of fibrinolytic system.
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Related Author
ZHANG Yuanyuan
JIN Peipei
BIAN Dong
GUO Dengzhou
ZHANG Yuanyuan
JIN Peipei
SONG Jingya
GUO Dengzhou
Related Institution
The First Affiliated Hospital of Hebei University of Chinese Medicine/Hebei Provincial Hospital of Traditional Chinese Medicine
Graduate School, Hebei University of Chinese Medicine
Affiliated Hospital of Hebei University of Chinese Medicine/Hebei Provincial Hospital of Traditional Chinese Medicine
Beijing University of Chinese Medicine
Xiyuan Hospital, China Academy of Chinese Medical Sciences