Objective: To investigate the effect of Tanreqing injection in treatment of acute lung injury (ALI) on pulmonary function and protective effects on vascular endothelial growth factor effects. Method: One hundred and twenty-four cases of ALI were randomly divided into the observation group and the control group (n=62 each)

the control group was received conventional emergency treatment

including venous channel establishment

circulatory support

oxygen supply

antibiotics and primary trauma treatment. On the basis of the measures in the control group

the observation group was given Tanreqing injection (20 mL in 5% glucose intravenous infusion of 250 mL) daily for 7 d. Blood gas indexes

systemic inflammatory response syndrome (SIRS) and Acute physiology and chronic health evaluation II (APACHE II) were investigated. Endothelin-1 (ET-1)

vascular endothelial growth factor (VEGF) and von willebrand factor (vWF) were determined. Result: After treatment for 3

7 days PO2

PCO2 and PO2/FiO2 in observation group were better than those in the control group significantly (P<0.01). After the treatment SIRS and APACHEⅡin observation group were lower than those in control group (P<0.05

P<0.01). After 3

7 days of treatment

ET-1

VEGF and vWF levels in the observation group were lower than those of the same period accordingly in the control group (P<0.01). Patients who needed mechanical ventilation and with pulmonary infection in observation group were less than that in control group (P<0.05). Conclusion: Tanreqing injection can decrease the serum ET-1

VEGF and vWF levels

reduce endothelial injury

reduce pulmonary edema

so it protects the lung function.