Objective: To evaluate the therapeutic effects of Qingre Sanwen oral liquid on children with hand

foot and mouth disease (HFMD). Method: Ninety-four patients with HFMD in our out-patient department were randomly divided into two groups. Forty-eight patients were treated with Qingre Sanwen oral liquid(5-10 mL

tid)

forty-six patients were treated with ribavirin (10-15 mg·kg-1·d-1). The treatment lasted for 3 days. Result: The marked effect rates were 63.82% and 56.81% in the observation group and in the controls accordingly without significant difference. The total effect rates were 93.64% and 86.36% in the observation group and in the controls respectively without significant difference. The observation group showed no adverse reaction. The control group had diarrhea in four cases and vomiting in 3 cases. Conclusion: Qingre Sanwen oral liquid has a good therapeutic effect on children with HFMD

and no adverse reactions.