Objective: To study the effects of the different extracts from modified Siwu Siteng decoction (TFT-I

TFT-Ⅱ) on acute gouty arthritis in rats induced by monosodium urate crystals. Method: SD rats were divided into normal group

model group

positive medicine diclofenac sodium group(0.007 g·kg-1)

TFT-I low and high dose group (1.24

2.48 g·kg-1)

TFT-Ⅱlow and high dose group(1.48

2.96 g·kg-1). The treatment groups were given corresponding drugs for 7 days. At 5th day monosodium urate method was used to establish model. Gaits of rats were observed at 24 h after modeling. Ankle joints' swelling degree at different time points after modeling was measured by paper tape. Interleukin-1β (IL-1β) and cyclooxygenase-2 (COX-2) levels were monitored by ELISA. Prostaglandine-2 (PGE2) levels were monitored by the principle of isomer. Result: Compared with normal group (0.07±0.01)cm

in model group

ankle joint swelling reached peak(0.52±0.02)cm at 8 h (P<0.05)

and IL-1β

COX-2 and PGE2 levels were increased (P<0.05). Compared with model group

TFT-I could significantly improve gaits of rats (P<0.05)

reduced ankle joints' swelling and the IL-1β

COX-2 and PGE2 level of rats' joint tissue (P<0.01). TFT-Ⅱ had no significant effect on swell improvement and inflammation factors inhibition. Conclusion: TFT-I has remarkable efficacy on symptom improvement in acute gouty arthritis rat induced by monosodium urate crystals

which may be related to its inhibiting IL-1β

COX-2 and PGE2 levels.