Evaluation of Antidepressant Effect of Tanshinol Sodium

SHI Cui-ge; LI Hui; WANG Li-li; WANG Ning; WANG Jie-dong; XU Zhi-qing; ZHANG Shu-cheng

doi:10.13422/j.cnki.syfix.2014070170

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Evaluation of Antidepressant Effect of Tanshinol Sodium

更新时间：2024-01-04

- Evaluation of Antidepressant Effect of Tanshinol Sodium
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 7, Pages: 170-173(2014)
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- DOI：10.13422/j.cnki.syfix.2014070170
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- Published：2014
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SHI Cui-ge, LI Hui, WANG Li-li, et al. Evaluation of Antidepressant Effect of Tanshinol Sodium[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(7): 170-173.
DOI：

SHI Cui-ge, LI Hui, WANG Li-li, et al. Evaluation of Antidepressant Effect of Tanshinol Sodium[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(7): 170-173. DOI： 10.13422/j.cnki.syfix.2014070170.

摘要

目的：研究丹参素钠的抗抑郁作用以及对PC12细胞损伤的保护作用。方法：在大鼠强迫游泳、小鼠强迫游泳、小鼠悬尾实验3种急性抑郁模型上，将动物随机分为空白对照组、丹参素钠低、中、高剂量组和阿米替林组，观察药物预先单次灌胃对大/小鼠强迫游泳不动时间、悬尾不动时间的影响；并在细胞水平建立皮质酮损伤PC12细胞模型，观察丹参素钠对PC12细胞存活率的影响。结果：在大鼠强迫游泳实验中，空白对照组不动时间为（139±34）s，丹参素钠（12，24，48 mg·kg-1）可分别缩短大鼠的强迫游泳不动时间至（107±23），（89±18），（76±18）s，与空白对照组相比有显著差异（P<0.05）；在小鼠强迫游泳和小鼠悬尾实验中，空白对照组不动时间分别为（123±39），（110±26）s，丹参素钠（18，36，72 mg·kg-1）可分别缩短小鼠的强迫游泳不动时间至（97±28），（89±23），（78±19）s；缩短小鼠的悬尾不动时间至（92±24），（83±26），（67±15）s，与空白对照组相比有显著差异（P<0.05）。PC12细胞经皮质酮损伤，细胞存活率显著降低吸光度（A）为0.68±0.08，与空白对照组A 1.41±0.39相比，有显著差异（P<0.05）。丹参素钠（1，10，100 mg·L-1）可显著提高 PC12细胞的存活率，与皮质酮组比较有显著差异。结论：丹参素钠具有抗抑郁作用，作用机制可能与其细胞保护作用有关。

Abstract

Objective: To investigate the antidepressant effect and the protective effects against neurotoxity of tanshinol sodium. Method: The animals were randomly divided into five groups:control group

low dose tanshinol sodium group

medium dose tanshinol sodium group

high dose tanshinol sodium group and amitriptyline group.The effects of tanshinol sodium on immobility time were deserved through the forced swimming test and tail suspension test in rats and mice. Likewise

PC12 cells injury was induced by corticosterone and the effect of tanshinol sodiumon the cell viability were measured by MTT assay. Result: In the rat forced swimming test

the immobility time in the control group was (139±34)s

tanshinol sodium (12

48 mg·kg-1) could shorten the immobility time to (107±23)

(89±18)

(76±18)s (compared with the control group

P<0.05).In the mouse forced swim and tail suspension test

the immobility time in control group was (123±39)

(110±26)s

tanshinol sodium (18

72 mg·kg-1) could shorten the forced swimming immobility time to (97±28)

(89±23)

(78±19)s

shorten the tail suspension immobility time to(92±24)

(83±26)

(67±15)s

there were significant differences compared with the control group(P<0.05). In addition

PC12 cell viability with treatment of corticosterone was significantly reduced (A) value (0.68±0.08)

there was a significant difference compared with the control group A value (1.41±0.39). Tanshinol sodium (1

100 mg·L-1) can significantly improve the survival rate of PC12 cells

there were asignificant differences compared with the corticosterone group. Conclusion: Tanshinol sodium possessed antidepressant effect

the mechanism may be related to its cytoprotective effect.

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