GAO Feng-hua, BAI Jing, LV Hua. Protective Effect of Total Flavones of Buckwheat Flower and Leaf on Adriamycin Induced Heart Failure in Rats and its Mechanism[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(7): 185-188.
DOI:
GAO Feng-hua, BAI Jing, LV Hua. Protective Effect of Total Flavones of Buckwheat Flower and Leaf on Adriamycin Induced Heart Failure in Rats and its Mechanism[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(7): 185-188. DOI: 10.13422/j.cnki.syfix.2014070185.
Protective Effect of Total Flavones of Buckwheat Flower and Leaf on Adriamycin Induced Heart Failure in Rats and its Mechanism
Objective: To observe effects of total flavones of buckwheat flower and leaf (TFBFL) on adriamycin induced heart failure in rats and its mechanism. Method: The rats were randomly divided into normal control group
heart failure model contrast group
TFBFL groups at different doses (100
200
400 mg·kg-1)and captopril group(10 mg·kg-1). The rat heart failure model was induced by intraperitoneal injection of adriamycin. The rats of each group were given therapeutic drugs by ig for 3 weeks. The cardiac function indexes were determined after the last administration. The levels of atrial natriuretic peptide(ANP) and brain natriuretic peptide (BNP) in serum were determined by radioimmunoassay. The levels of nitric oxide (NO)
nitric oxide synthase (NOS)
interleukin-1β(IL-1β)
interleukin-6(IL-6)and tumor necrosis factor-α (TNF-α) were determined by enzyme-linked immunosorbent assay (ELISA). Result: Compared with the normal control group
the myocardial infarction indexes such as left ventricular systolic pressure (LVSP)
left ventricular end-diastolic pressure LVEDP)and ±dp/dtmax
and the levels of ANP
BNP
NO
NOS
IL-1β
IL-6 and TNF-α in serum were increased remarkably(P<0.05
P<0.01). But compared with the model group
the myocardial infarction indexes and the levels of ANP
BNP
NO
NOS
IL-1β
IL-6 and TNF-α in serum were decreased to some extent(P<0.05
P<0.01). Conclusion: TFBFL could improve cardiac function of heart failure induced by adriamycin
which may be related to decreasing the levels of ANP
Protective Effects of Buckwheat Flavones on Diabetic Nephropathy Rats
Analysis of Potential Active Components and Molecular Mechanism of Baoxin Granules Regulating Ferroptosis in Treatment of Heart Failure
Effect of Qingxin Jieyu Granules Regulating Mitophagy on Ventricular Remodeling After Myocardial Infarction of C57B/L6 Mice
Material Basis and Its Distribution in vivo of Qili Qiangxin Capsules Analyzed by UPLC-Q-Orbitrap-MS
Effect of Serum Containing Zhenwutang on Apoptosis of Myocardial Mast Cells and Mitochondrial Autophagy
Related Author
LIU Xiao-na
WANG Lan-ying
PENG Jian-xia
TANG Li-min
LI Hong
CHEN Yu
WANG Maolin
WANG Yun
Related Institution
Jiangxi University of Chinese Medicine
Center for Food Evaluation,State Administration for Market Regulation
Jiangxi Province Key Laboratory of Traditional Chinese Medicine(TCM) Pharmacology,Institute of TCM Health Industry,China Academy of Chinese Medical Sciences
State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences
Research Institute of Integrated Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine