Tongguan Fumai Decoction to Treat Ventricular Premature Beat in Coronary Heart Disease of 38 Cases

YAN Ming-ying; DENG Zhi; XU De-wei; JIANG Yu

doi:10.13422/j.cnki.syfix.2014070199

您当前的位置：

首页 >

文章列表页 >

Tongguan Fumai Decoction to Treat Ventricular Premature Beat in Coronary Heart Disease of 38 Cases

更新时间：2024-01-04

- Tongguan Fumai Decoction to Treat Ventricular Premature Beat in Coronary Heart Disease of 38 Cases
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 7, Pages: 199-203(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfix.2014070199
  CLC：
- Published：2014
- 稿件说明：
移动端阅览
YAN Ming-ying, DENG Zhi, XU De-wei, et al. Tongguan Fumai Decoction to Treat Ventricular Premature Beat in Coronary Heart Disease of 38 Cases[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(7): 199-203.
DOI：

YAN Ming-ying, DENG Zhi, XU De-wei, et al. Tongguan Fumai Decoction to Treat Ventricular Premature Beat in Coronary Heart Disease of 38 Cases[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(7): 199-203. DOI： 10.13422/j.cnki.syfix.2014070199.

摘要

目的：探讨通冠复脉汤治疗冠心病（CHD）室性早搏的临床疗效及对血管内皮功能的影响。方法：将77例CHD室性早搏急患者按住院先后随机分为对照组39和观察组38例。两组均给予常规西医治疗，对照组，美托洛尔缓释片，50 mg/次，1次/d。观察组在对照组的基础上加服通冠复脉汤，1剂/d，常规水煎分2次服用。两组疗程均为12周。记录治疗前后心悸、胸痛、神疲乏力、气短及唇色紫暗等主要症状评分；采用24 h动态心电图记录治疗前后室性早搏的次数；记录每周心绞痛发作次数及每次持续时间；检测治疗前后血清一氧化氮（NO），内皮素1（ET-1），血栓素（TXB2）及6-酮-前列腺素F_（1a）（6-Keto-PGF_1a）水平。结果：观察组心律失常总有效率为92.11%，优于对照组的74.36%（P<0.05）；经Ridit分析，观察组心电图疗效优于对照组（P<0.05）；治疗后观察组心绞痛发作次数及持续时间均少于对照组（P<0.05或P<0.01）；观察组心悸、胸痛、神疲乏力、气短及唇色紫暗等症状评分低于对照组（P<0.01）；观察组NO和6-Keto-PGF-1a高于对照组，ET-1和TXB2低于对照组（P<0.01）。结论：通冠复脉汤能治冠心病（CHD）室性早搏患者临床症状、心电图缺血改变、室性早搏均有显著改善作用，临床疗效显著，其作用机制可能与改善患者血管内皮功能，增加心肌血供有关。

Abstract

Objective: The purpose is to discuss the clinical effects of Tongguan Fumai decoction on ventricular premature beat in coronary heart disease (CHD) and the influence of vascular endothelial function. Method: Seventy-seven cases of patients with were randomly divided into control group (39 cases) and observation group (38 cases) according to the oder of being in hospital.Both groups were treated with regular western medicine treatment.In control group

patients took metoprolol sustained-release tablets

50 mg/time

1 does/day.For patients in observation group took Tongguan Fumai decoction based on control group

1 does/day

conventional water decoction

taken orally.The treatment course was 12 weeks for both groups.Record symptom score of palpitation

chest pain

spirit fatigue

breathe hard and dark purple color on lip before and after treatment. Keep a record of the number of ventricular premature beat by 24 hours dynamic electrocardiogram.Besides

record number of angina pectoris attack times and duration time within a week.Detect serum nitric oxide(NO)

endothelin-1(ET-1)

thromboxane (TXB2) and 6-ketone-prostaglandin F_(1a) (6-Keto-PGF_1a) before and after treatment. Result: After the treatment

total effective rate of arrhythmia in observation group was 92.11%

which was better than 74.36% in control group(P<0.05).Electrocardiograph curative effect in observation group was superior to control group(P<0.01) by analysis of Ridit.The number of angina pectoris attack times and duration time in observation group were both lower than control group(P<0.05 or P<0.01) after treated.Symptom score of palpitation

chest pain

spirit fatigue

breathe hard and dark purple color on lip in observation group were inferior to control group(P<0.01).For observation group

the level of NO and 6-Keto-PGF_1a were higher than control group

but ET-1 and TXB2were lower (P<0.01). Conclusion: Through the treatment of Tongguan Fumai decoction. It can improve patients with CHD ventricular premature beat in clinical symptoms

electrocardiograph ischemia change and ventricular premature beat.As for the effective clinical effects

its mechanism of action may be because it improve patients' vascular endothelial function and increase myocardial blood supply.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Danhong Injection on Adverse Cardiac Events After Percutaneous Coronary Intervention

Treatment of Modified Wumei Pills on 40 Cases with Ventricular Premature Systole of Coronary Heart Disease

Establishment and Evaluation of Rat Model of Myocardial Ischemia-reperfusion Injury with Phlegm and Blood Stasis Blocking Collaterals Syndrome Based on Metabolomics

Establishment and Evaluation of Rat Model of Acute Myocardial Infarction in Coronary Heart Disease with Qi and Yin Deficiency Syndrome Based on Sleep Deprivation Combined with Coronary Artery Ligation

Mechanism of Xuefu Zhuyutang in Intervening in Ferroptosis in Rats with Coronary Heart Disease with Blood Stasis Syndrome Based on ACSL4 Signalling Pathway

Related Author

ZHANG Tao

CHEN Hui

HUANG Jia-shu

SHEN Tao

SONG Kun-peng

WU Jian-guang

LAI Jun-yu

HU Longxiao

Related Institution

Natural History Museum of China

Beijing Key Laboratory of Chinese Materia Pharmacology，National Clinical Research Center of Traditional Chinese Medicine for Cardiovascular Diseases，Institute of Basic Medical Sciences， Xiyuan Hospital，China Academy of Chinese Medical Sciences

School of Clinical Medicine，Beijing University of Chinese Medicine

Institute of Basic Medical Sciences，Xiyuan Hospital，China Academy of Chinese Medical Sciences

Provincial Key Laboratory of Traditional Chinese Medicine（TCM） Diagnostics， Hunan University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰