Clinical Research of Bufei Huazhuo Cream Party Treatment on Chronic Obstructive Pulmonary Disease at Stable Phase

ZHAO Jian-jun; QIN Jian-ping; TANG Shu-fu; WANG Tao

doi:10.13422/j.cnki.syfix.2014070216

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Clinical Research of Bufei Huazhuo Cream Party Treatment on Chronic Obstructive Pulmonary Disease at Stable Phase

更新时间：2024-01-04

- Clinical Research of Bufei Huazhuo Cream Party Treatment on Chronic Obstructive Pulmonary Disease at Stable Phase
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 7, Pages: 216-219(2014)
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- DOI：10.13422/j.cnki.syfix.2014070216
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- Published：2014
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ZHAO Jian-jun, QIN Jian-ping, TANG Shu-fu, et al. Clinical Research of Bufei Huazhuo Cream Party Treatment on Chronic Obstructive Pulmonary Disease at Stable Phase[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(7): 216-219.
DOI：

ZHAO Jian-jun, QIN Jian-ping, TANG Shu-fu, et al. Clinical Research of Bufei Huazhuo Cream Party Treatment on Chronic Obstructive Pulmonary Disease at Stable Phase[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(7): 216-219. DOI： 10.13422/j.cnki.syfix.2014070216.

摘要

目的：观察补肺化浊膏方对慢性阻塞性肺疾病（COPD）稳定期患者肺功能和生活质量的影响。方法：将90例COPD稳定期患者随机按数字表分为观察组和对照组各45例。对照组采用沙美特罗替卡松粉吸入剂，1吸/次，早晚各1次；痰多者给予盐酸氨溴索片，2片/次，3次/d；气喘明显者给予氨茶碱片，0.2 g/次，3次/d。观察组在对照组治疗的基础上加服补肺化浊膏方，15 g/次，3次/d。两组疗程均为24周。治疗前后进行肺功能检测，记录治疗前后气流阻塞、呼吸困难、运动能力（BODE）指数和主要症状评分，采用圣乔治呼吸问卷（SGOR）评价生活质量。结果：观察组总有效率93.33%优于对照组的77.78%（P<0.05）；治疗后观察组1 s用力呼气容积（FEV1），用力肺活量（FVC）和FEV1/FVC均较治疗前上升，并高于对照组（P<0.05）；治疗后观察组症状、体征评分低于对照组（P<0.01）；治疗后观察组呼吸症状、活动能力及疾病影响3个维度和SGOR总评分均低于对照组（P<0.01）；治疗后观察组气流阻塞程度，呼吸困难及6 min步行距离3个维度和BODE指数评分均低于对照组（P<0.01）。结论：补肺化浊膏方改善了COPD稳定期患者的肺功能，延缓了肺功能的下降，减轻了临床症状，提高了患者生活质量，临床疗效显著，值得临床推广使用。

Abstract

Objective: The purpose is to observe the clinical effects of Bufei Huazhuo cream party to treat chronic obstructive pulmonary disease(COPD) at stable phase and the influence of Bufei Huazhuo cream party on cure of patients' lung function and living quality in stable period. Method: Ninety hundred cases of patients were randomly divided into control group (45 cases) and observation group (45 cases) by numeration table.The patients in the control group took salmeterol assigned powder inhaler

1 absorption/time

in each morning and night.For patients who had excessive phlegm

took ambroxol hydrochloride tablets

2 pieces/time

3 times/day.Those who had obvious asthma took aminophylline tablets

0.2 g/time

3 times/day.Based on control group's treatment

observation group added Bufei Huazhuo cream party

15 g/time

3 times/day.Treatment courses for two groups continued 24 weeks.Detect lung function and record airflow obstruction

dyspnea

exercise capacity(BODE)index

main symptom scores before and after treatment.Evaluate quality of life using St.George's respiratory questionnaire(SGOR). Result: The total effective rate of observation group was 93.33%

which is better than 77.78% of control group (P<0.05).After the treatment

the level of forced vital capacity(FVC)

forced expiratory volume in 1 second (FEV1) and FVC/FEV1 all got ascended.Besides these data were superior to control group (P<0.05). Symptoms and signs scores of observation group were lower than those in control group (P<0.01) after treatment. Respiratory symptoms

capacity action

disease influence of 3 dimensionality and SGOR total scores in observation group were all inferior to these data in control group.Moreover

degree of airflow obstruction

dyspnea

3 dimensionality of 6 min walk distance(6 MWD) and BODE index scores were lower than those in control group. Conclusion: Bufei Huazhuo cream party improved lung function of COPD patients at stable phase

delayed lung function decline

relieved clinical symptoms and enhanced patients' living quality.The clinical curative effect is obvious.It deserves clinical use.

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