Optimization of Ultrafine Grinding Technology for Chuanxiong Rhizoma by Box-Behnken Design

XIANG Sun-min; YANG An-dong; ZHU Ning; LU Duo; HAO Yue-pu; QIN Chun-feng

doi:10.13422/j.cnki.syfix.2014080015

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Optimization of Ultrafine Grinding Technology for Chuanxiong Rhizoma by Box-Behnken Design

更新时间：2024-01-04

- Optimization of Ultrafine Grinding Technology for Chuanxiong Rhizoma by Box-Behnken Design
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 8, Pages: 15-18(2014)
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- DOI：10.13422/j.cnki.syfix.2014080015
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- Published：2014
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XIANG Sun-min, YANG An-dong, ZHU Ning, et al. Optimization of Ultrafine Grinding Technology for Chuanxiong Rhizoma by Box-Behnken Design[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(8): 15-18.
DOI：

XIANG Sun-min, YANG An-dong, ZHU Ning, et al. Optimization of Ultrafine Grinding Technology for Chuanxiong Rhizoma by Box-Behnken Design[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(8): 15-18. DOI： 10.13422/j.cnki.syfix.2014080015.

摘要

目的：优选川芎的超微粉碎工艺。方法：选择投料量、含水量、粉碎时间为自变量，平均粒径为因变量，通过Box-Behnken响应面法优选川芎的超微粉碎工艺，并考察超微粉碎前后的粉体学性质和吸湿性。结果：最佳超微粉碎工艺为投料量1.3 kg，含水量4%，粉碎时间19 min；平均粒径19.187 μm，与模型预测值18.357 7 μm的偏差仅4.5%。川芎普通粉末和超微粉的休止角分别为（49.4±0.03），（50.2±0.02）°，松密度分别为（0.429±0.003），（0.363±0.005） g·mL-1，振实密度分别为（0.609±0.05），（0.556±0.10） g·mL-1，吸湿平衡时间均约80 h。结论：优选的超微粉碎工艺合理可行，川芎超微粉的制剂过程中需加入助流剂等辅料以改善粉体的流动性，川芎超微粉碎过程中宜严格控制湿度。

Abstract

Objective: To optimize ultrafine grinding process of Chuanxiong Rhizoma. Method: Taking feeding amount

moisture content and grinding time as independent variables

average particle size as dependent variable

Box-Behnken response surface methodology was adopted to optimizeultrafine grinding process of Chuanxiong Rhizoma

its powder properties and hygroscopicity before and after smashed were investigated. Result: Optimum ultrafine grinding process was as follows:feeding amount1.3 kg

moisture content 4%

grinding time 19 min;Deviation between the predicted value(18.357 7 μm) and the measured value(19.187 μm) of average particle size was only 4.5%.Response angles of ordinary and ultrafine powder were (49.4±0.03) and (50.2±0.02) °

bulk densities were (0.429±0.003) and (0.363±0.005) g·mL-1

tap densities were (0.609±0.05) amd (0.556±0.10) g·mL-1

moisture equilibrium times were about 80 h. Conclusion: Optimized ultrafine grinding process was reasonable and feasible

preparation technology of ultrafine powder of Chuanxiong Rhizoma should add flow aid and other auxiliary materials in order to improve fluidity of powder

ultrafine grinding process should strictly control humidity.

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