MENG Tian-xiu, GONG Zhi-qiang, HUANG Zhen-yuan, et al. Effects of Different Extracts of on Lipid Metabolism of Quails[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(8): 166-169.
DOI:
MENG Tian-xiu, GONG Zhi-qiang, HUANG Zhen-yuan, et al. Effects of Different Extracts of on Lipid Metabolism of Quails[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(8): 166-169. DOI: 10.13422/j.cnki.syfix.2014080166.
Effects of Different Extracts of on Lipid Metabolism of Quails
Objective: To explore the effects of different extracts of Rhinacanthus nasutus (DER) on lipid metabolism of the quails. Method: The quails were randomly divided into 11 groups
each included 12 quails:normal control group
model group
Zhibituo (2.0 g·kg-1) positive control group
high dose and low dose (21.6
5.4 g·kg-1) groups of three extracts of DER. The quails atherosclerotic model was established by feeding high fat food.The administration lasted three months. Total cholesterol(TC)
triglycerides(TG)
high density lipoprotein cholestero(HDL-C) and low density lipoprotein cholesterol(LDL-C) levels were measured
the tissues of aorta and liver were observed under light microscope. Result: Compared with normal control group
the content of TC
TG
LDL-C of model group was increased(P<0.01). Compared with model group
the end of 3nd month after administration
the content of TC
TG
LDL-C in DER groups was decreased obviously (P<0.05-P<0.01)
content of HDL-C was increased
there were significant differences. The effects of ethyl acetate and butanol effective parts was better than petroleum and water extrats;and the pathological lesions of atherosclerotic plaque were significantly lessened. Conclusion: Extraction of R. nasutus can effectively decrease the serum lipid and prevent the formation of atherosclerosis.
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