LIU Ting, XIAO Zhen-dong, LI Pei-pei. Liqi Huatan Qutan Method Treatment on Coronary Heart Disease Combine Hyperlipidaemia (Stasis Stagnation Syndrome) with 45 Cases[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(8): 221-225.
DOI:
LIU Ting, XIAO Zhen-dong, LI Pei-pei. Liqi Huatan Qutan Method Treatment on Coronary Heart Disease Combine Hyperlipidaemia (Stasis Stagnation Syndrome) with 45 Cases[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(8): 221-225. DOI: 10.13422/j.cnki.syfix.2014080221.
Liqi Huatan Qutan Method Treatment on Coronary Heart Disease Combine Hyperlipidaemia (Stasis Stagnation Syndrome) with 45 Cases
Objective: The purpose is to observe the clinical effects of Banxiao Baizhu Tianma decoction combined with Danshen decoction add and subtract treatment on coronary heart disease stable angina pectoris combine hyperlipidaemia(stasis stagnation syndrome).Beside
to observe the influence of these treatment on lipoprotein associated phospholipase A2(Lp-PLA2)
α-granule membrane protein on platelet surface(GMP-140) and platelet maximum condensation rate (ADP). Method: Ninety cases of patients were randomly divided into control group (45 cases) and observation group (45 cases) by sequential order of outpatient. Both groups received basic treatment
including bayaspirin enteric-coated tablets
0.1 g/time
1 piece/day
taken sublingual buccal immunotherapy.Nitroglycerin tablets
1 piece/day
taken buccally when necessary.For patients in control group
they took atorvastatin
20 mg/time
1 does/day
taken orally.Patients in observation group took Banxiao Baizhu Tianma decoction combined Danshen decoction
1 does/day.Treatment courses continued 12 weeks.Detect blood lipid level
record attack frequency of angina pectoris each week and nitroglycerin tablet before and after treatment.Conduct electrocardiographic examination before and after treatment.Test the level of Lp-PLA2
GMP-140
high-sensitivity C-reactive protein(hs-CRP)and ADP. Result: The total curative effective rate of electrocardiogram of the observation group was 82.0% superior to 60% of the control group(P<0.05)
for the observation group
the time of stenocardia and the dosage of nitroglycerin tablets were both less than that of the control group(P<0.01)
and the total curative effective rate of reducing lipid of the observation group was 95.6% higher than 91.1% of the control group
and there was no statistically significant difference
after treatment
the level of cholesterol(TC) and triglyceride(TG) of the observation group was lower than that of the control group(P<0.01)
and there was no statistically significant difference between low density lipoprotein cholesterol(LDL-C) group and high density lipoprotein cholesterol(HDL-C) group
Besides
the level of Lp-PLA2
GMP-140
hs-CRP and ADP of the observation group were all lower than that of the control group(P<0.01). Conclusion: It can ameliorate patients' level of blood lipid of when Banxia Baizhu Tianma decoction which combined with Danshen decoction was used in coronary heart disease and stable angina pectoris pooling hyperlipidemia
and it can also relief angina symptom
we can get comprehensive curative effect. What's more it can relief inflammatory factors
inhibit platelet aggregation
there is a preventive effect to adverse events coronary heart disease.
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Addition and Subtraction Therapy of Zhishi Xiebai Guizhitang and Lizhongtang for Stable Angina and Effect on Inflammatory Factors and Endothelial Function
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ZHAO Zhiru
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Related Institution
Xiyuan Hospital, China Academy of Chinese Medical Sciences
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