Objective: To optimize extraction technology of Jiedu Tongluo particles. Method: Based on single factor tests

central composite design-response surface methodology was applied to optimize extraction process with soaking time

decoction time and solvent amounts as independent variables

while composite score of extraction amounts of baicalin

quercetin and isorhamnetin as dependent variable.SPSS software was used to fit multivariate linear equation and second-order polynomial equation for experimental data

response surface and contour plot were delineated according to best-fit mathematic models by Design Expert 8.0.0 statistic analysis software. Result: Optimum extraction process was as follows:soaking time 90 min

decoction time 85.63 min

the amount of solvent 9.21 times;Composite score was (93.2±0.051) %

which had deviation of -2.32% with the predicted value of 94.30%. Conclusion: Model established by central composite design-response surface methodology had good predictability

which was suitable for optimizing extraction process of Jiedu Tongluo particles.