Track the Content Change of Three Kinds of Lactones in the Process of Chuanxinlian Injection

LU Xin-hua; LONG Xiao-ying; LUO Jia-bo; TAN Xiao-mei; CUI Meng-fei

doi:10.13422/j.cnki.syfix.2014090043

您当前的位置：

首页 >

文章列表页 >

Track the Content Change of Three Kinds of Lactones in the Process of Chuanxinlian Injection

更新时间：2024-01-04

- Track the Content Change of Three Kinds of Lactones in the Process of Chuanxinlian Injection
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 9, Pages: 43-46(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfix.2014090043
  CLC：
- Published：2014
- 稿件说明：
移动端阅览
LU Xin-hua, LONG Xiao-ying, LUO Jia-bo, et al. Track the Content Change of Three Kinds of Lactones in the Process of Chuanxinlian Injection[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(9): 43-46.
DOI：

LU Xin-hua, LONG Xiao-ying, LUO Jia-bo, et al. Track the Content Change of Three Kinds of Lactones in the Process of Chuanxinlian Injection[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(9): 43-46. DOI： 10.13422/j.cnki.syfix.2014090043.

摘要

目的：通过研究穿心莲注射液工艺过程中穿心莲内酯、新穿心莲内酯以及脱水穿心莲内酯含量的动态变化来加强穿心莲注射液的质量控制。方法：模拟穿心莲注射液生产工艺，并从中选取6个关键工艺作为监控点，利用UV-HPLC对其进行在线质量监测，追踪穿心莲内酯、新穿心莲内酯以及脱水穿心莲内酯含量的动态变化，计算转移率。结果：穿心莲内酯、新穿心莲内酯以及脱水穿心莲内酯在整个生产工艺中总的转移率不同，总的转移率分别是56.3%，74.0%，42.5%；3种内酯在不同的生产工艺转移率亦不同，在活性炭回流脱色工艺中的损失最为严重，总内酯类成分转移率仅为75.2%。结论：将穿心莲注射液的质量控制由从药材、中间体、制剂的静态控制变为对工艺过程的动态监控全方位的控制，可更准确地分析可能存在质量问题的环节，为相关生产企业实际生产提供参考，并为提高穿心莲注射液乃至中药注射剂的质量可控性奠定基础，具有较高的参考价值。

Abstract

Objective: To strength the quality control method of Chuanxinlian injection by determining the content of andrographolide

neoandrographolide and dehydroandrographolide in the process of production. Method: Adopt UV-HPLC to track the dynamic variation of andrographolide

neoandrographolide and dehydroandrographolide in six key process steps

which were picked up from Chuanxinlian injection production process. And metastasis rate of 3 kinds of lactones were analyzed. Result: During the production

the metastasis rate of Andrographolide

neoandrographolide and dehydroandrographolide is different. It is 56.3%

74.0% and 42.5% respectively. The metastasis rate of three kinds of lactones in different production process is different. The loss in the progress of decolorization activated carbon is most serious. And the metastasis rate of three kinds of lactones is only 75.2%. Conclusion: This research may give a mind of Chuanxinlian injection quality control change from static control to dynamic control. And a great number of possible quality problems in the process of production may be analyzed and summarized more accurate. It provides a solid scientific experimental basis for practical production of Chuanxinlian injection and feasible recommendations for related manufacturing enterprises. Therefore

this paper could offer a new thought for quality control of Chuanxinlian injection even traditional Chinese medicine injections.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

HPLC Determination of Andrographolide and Dehyandrographolide in Fukeqianjin Capsules

Determination of Content Change of Two Lactone Ingredients from Andrographis Herba after Compatibility with Artemisiae Scopariae Herba by HPLC

HPLC Determination of Geniposide, Andrographolide and Dehydroandrographolide in Lianzhi Qinghuo Capsules

Tracking Changes of Three Andrographolides Content in Production Process of Chuanwang Xiaoyan Capsules

Related Author

GUO Yan-rong

LU Hua

TU Yao-sheng

FU Jian-wu

SUN Dong-mei

ZHANG Jian-jun

JIANG Zhi-qiang

LI Shao-lin

Related Institution

Guangdong Province Municipal Institute of Traditional Chinese Medicine

Guangzhou University of Chinese Medicine

fong Pharmaceutical Corporation,Foshan

Guangxi University of Chinese Medicine

Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine，Guangxi University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰