Objective: To study the effects of Weipixiao

which has functions of fortifying the spleen

dissipating blood stasis

and detoxifying

on gastric precancerous lesions (GPL) and the related molecular mechanisms. Method: SD rats were randomly divided into normal group

model group

Weimeisu group (0.2 g·kg-1·d-1)

Weipixiao high dose

middle dose and low dose groups (15

7.5

3.75 g·kg-1·d-1). Except for normal group

the rats in other groups were provided with spontaneous intake of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) solution

irregular diet and purgative herbs to establish GPL rat model for 18 consecutive weeks. At the beginning of 9th week

the mediation groups were provided with treatment for 10 weeks at corresponding doses mentioned above

and the expression of nuclear factor-kappa B ( NF-κB) p65 in gastric mucosal epithelial cells was observed. Result: Compared with normal group

the scores of NF-κB p65 expression in gastric mucosal epithelial cells of the model group were significantly higher (P<0.01)

but decreased in three different dosage of Weipixiao groups (P<0.05)

particularly in Weipixiao low dose group (P<0.05). Conclusion: Weipixiao could significantly inhibit the aberrant activation of NF-κB signaling pathway

down-regulating the expression of NF-κB p65 protein.Weipixiao

might probably inhibit the proliferation

invasion and metastasis of atypical cells

as a consequence it can prevent and cure gastric precancerous lesions.