Effect of Inactivated Sera of Rats with the Treatment of Guizhi-Tang   on HSV-1-induced Cellular Pathologic Changes

HE Yu-zhuo; GAO Ying-jie; SHEN Hong; CUI Xiao-lan; GUO Shu-ying; JIANG Ting-liang

doi:10.13422/j.cnki.syfjx.2000.02.010

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Effect of Inactivated Sera of Rats with the Treatment of Guizhi-Tang on HSV-1-induced Cellular Pathologic Changes

更新时间：2024-09-23

- Effect of Inactivated Sera of Rats with the Treatment of Guizhi-Tang on HSV-1-induced Cellular Pathologic Changes
- Chinese Journal of Experimental Traditional Medical Formulae Issue 2, Pages: 20-23(2000)
- 作者机构：
  
  中国中医研究院中药研究所!北京100700
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2000.02.010
  CLC： R285
- Published：2000
- 稿件说明：
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[1]贺玉琢,高英杰,沈鸿,崔晓兰,郭淑英,姜廷良.给予桂枝汤的大鼠血清灭活对HSV-1致细胞病变的影响[J].中国实验方剂学杂志,2000(02):20-23.

HE Yu-zhuo, GAO Ying-jie, SHEN Hong, et al. Effect of Inactivated Sera of Rats with the Treatment of Guizhi-Tang on HSV-1-induced Cellular Pathologic Changes[J]. Chinese journal of experimental traditional medical formulae, 2000, (2): 20-23.
[1]贺玉琢,高英杰,沈鸿,崔晓兰,郭淑英,姜廷良.给予桂枝汤的大鼠血清灭活对HSV-1致细胞病变的影响[J].中国实验方剂学杂志,2000(02):20-23. DOI： 10.13422/j.cnki.syfjx.2000.02.010.

HE Yu-zhuo, GAO Ying-jie, SHEN Hong, et al. Effect of Inactivated Sera of Rats with the Treatment of Guizhi-Tang on HSV-1-induced Cellular Pathologic Changes[J]. Chinese journal of experimental traditional medical formulae, 2000, (2): 20-23. DOI： 10.13422/j.cnki.syfjx.2000.02.010.

摘要

将灌服桂枝汤后大鼠血清灭活，观察灭活前后血清对ＨＳＶ－１致ＣＰＥ的作用。结论是在以给药后的动物血清进行体外试验时，①要设正常动物血清对照，以观察正常动物血清本身的作用，②采用灭活后的含药血清为好，以去除血清中抗体与补体。③可根据中药复方的特点，以相当于临床等效剂量为中心，多设几个剂量组，以便正确判断含药血清的真正药效。

Abstract

The drug-containing sera from the rats with oral administration of Guizhi-Tang were inactivated.The effects of the sera with or without inactivation were investigated on HSV\|1\|induced CPE action.The result showed that the following measures should be taken when the sera of animals post\|administration of Chinese medicine were used in an in vitro study:（1）A serum control should be set to establish the effect of serum itself on the study system.（2）It could be better to use inactivated drug-containing sera because the antibody and complement of the sera could be eliminated after inactivation.（3）More doses considering the clinical equivalent effect\|dose as the middle one should be designed according to the characteristics of Chinese prescription to correctly evaluate the real effect of drug-containing sera.

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HE Yu-zhuo

GAO Ying-jie

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GUO Shu-ying

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Related Institution

Jiangxi University of Chinese Medicine

Affiliated Hospital of Jiangxi University of Chinese Medicine

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中国中医科学院中药研究所唐氏中药研究中心北京100700

Institute of Chinese Materia Medica,China Academy of Traditional Chinese Medicine

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