Cerebrovascular Effect of Geng Sai Tong in Animals

XIA Yi-wu; HUANG Mang-li; XIONG Wei; WU Yi-fan

doi:10.13422/j.cnki.syfjx.2001.05.015

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Cerebrovascular Effect of Geng Sai Tong in Animals

更新时间：2024-09-23

- Cerebrovascular Effect of Geng Sai Tong in Animals
- Chinese Journal of Experimental Traditional Medical Formulae Issue 5, Pages: 31-34(2001)
- 作者机构：
  
  湖北省药品检验所,武汉,430064
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2001.05.015
  CLC： R285.5
- Published：2001
- 稿件说明：
移动端阅览
[1]夏义武,黄芒莉,熊玮,吴亦帆.梗塞通对动物脑血管的影响[J].中国实验方剂学杂志,2001(05):31-34.

XIA Yi-wu, HUANG Mang-li, XIONG Wei, et al. Cerebrovascular Effect of Geng Sai Tong in Animals[J]. Chinese journal of experimental traditional medical formulae, 2001, (5): 31-34.
[1]夏义武,黄芒莉,熊玮,吴亦帆.梗塞通对动物脑血管的影响[J].中国实验方剂学杂志,2001(05):31-34. DOI： 10.13422/j.cnki.syfjx.2001.05.015.

XIA Yi-wu, HUANG Mang-li, XIONG Wei, et al. Cerebrovascular Effect of Geng Sai Tong in Animals[J]. Chinese journal of experimental traditional medical formulae, 2001, (5): 31-34. DOI： 10.13422/j.cnki.syfjx.2001.05.015.

摘要

方法 :梗塞通以 3个剂量给犬、大鼠及小鼠灌胃给药后

测定麻醉犬的颈总动脉及颈内动脉血流量

测定麻醉大鼠的颈总动脉血流量

测定脑缺血模型大鼠的脑含水量及脑血管通透性

测珲脑血循环障碍及常压下缺氧小鼠的存活时间

测定小鼠的凝血时间。结果表明 :梗塞通能明显增加犬、大鼠脑内血流量 ;能明显降低脑缺血大鼠的脑含水量及脑血管通透性的增加 ;能显著延长脑血循环障碍及常压下缺氧小鼠的存活时间 ;也能显著延长小鼠凝血时间。

Abstract

Geng Sai Tong（GST） was orally administrated to dogs

rats and mice. Then the volume of blood flow in carotid and intra-carotid of anesthetic dogs

and in carotid of anesthetic rats was determined. The water content and the blood vessel permeability of the brain of rats with brain ischemia were checked

The living time of mice under the condition of brain ischemia and without oxygen

and the time of blood coagulation of mice was also checked

The results showed that GST can markedly increase the volume of blood flow in the brain of dogs and rats

and can significantly decrease lift of the water content and the blood vessel permeability of the brain of the rats with brain ischemia

and can markedly prolongate the living time of mice under the condition of brain ischemia and without oxygen and the time of blood coagulation in mice.

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Related Author

XIA Yi-wu

HUANG Mang-li

XIONG Wei

WU Yi-fan

YU Meishuang

DAI Guoliang

HANG Huaxi

YE Yu

Related Institution

Affiliated Hospital of Nanjing University of Chinese Medicine

School of Pharmacy，Liaoning University of Traditional Chinese Medicine

College of Chinese Medicine， Beijing Research Institute of Chinese Medicine， College of Life Science， Beijing University of Chinese Medicine

School of Pharmacy,Jiangxi University of Traditional Chinese Medicine

Engineering Technology Research Center for Chinese Materia Medica Quality of Universities in Guangdong Province, Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica, State Administration of Traditional Chinese Medicine(TCM), School of TCM, Guangdong Pharmaceutical University

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