Effect of Yang Shou Dan on IL-1 β、 AchE Response Elements of APP Protein  in Rat Model with Alzheimer’s Disease Combining Yang Deficiency of Kidney

LIU Ming-ping1; HUANG Zhao-sheng1; SUN Wei-guang2

doi:10.13422/j.cnki.syfjx.2003.05.010

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Effect of Yang Shou Dan on IL-1 β、 AchE Response Elements of APP Protein in Rat Model with Alzheimer’s Disease Combining Yang Deficiency of Kidney

更新时间：2024-09-23

- Effect of Yang Shou Dan on IL-1 β、 AchE Response Elements of APP Protein in Rat Model with Alzheimer’s Disease Combining Yang Deficiency of Kidney
- Chinese Journal of Experimental Traditional Medical Formulae Issue 5, Pages: 19-21(2003)
- 作者机构：
  
  1.   广州中医药大学中药学院
  2.   广州星群药业股份有限公司广东广州510405
  3.   广东广州510420
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2003.05.010
  CLC： R285.5
- Published：2003
- 稿件说明：
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[1]刘明平,黄兆胜,孙维广.养寿丹对Alzheimer病肾阳虚模型大鼠中枢胆碱能神经递质和细胞因子的影响[J].中国实验方剂学杂志,2003(05):19-21.

LIU Ming-ping1, HUANG Zhao-sheng1, SUN Wei-guang2. Effect of Yang Shou Dan on IL-1 β、 AchE Response Elements of APP Protein in Rat Model with Alzheimer’s Disease Combining Yang Deficiency of Kidney[J]. Chinese journal of experimental traditional medical formulae, 2003, (5): 19-21.
[1]刘明平,黄兆胜,孙维广.养寿丹对Alzheimer病肾阳虚模型大鼠中枢胆碱能神经递质和细胞因子的影响[J].中国实验方剂学杂志,2003(05):19-21. DOI： 10.13422/j.cnki.syfjx.2003.05.010.

LIU Ming-ping1, HUANG Zhao-sheng1, SUN Wei-guang2. Effect of Yang Shou Dan on IL-1 β、 AchE Response Elements of APP Protein in Rat Model with Alzheimer’s Disease Combining Yang Deficiency of Kidney[J]. Chinese journal of experimental traditional medical formulae, 2003, (5): 19-21. DOI： 10.13422/j.cnki.syfjx.2003.05.010.

摘要

目的 :观察养寿丹对淀粉样前体蛋白基因启动因子IL 1β、AChE的影响。方法 :用D 半乳糖致亚急性衰老、醋酸氢化可的松致肾阳虚合并Meynert核损毁造成阿尔茨海默病肾阳虚大鼠模型

检测大鼠脑组织内IL 1β、AchE的含量。结果 :模型组大鼠脑组织IL 1β含量较正常组大鼠显著增高（P <0 0 1） ;与模型组比较养寿丹高、低剂量组和脑复康组大鼠脑IL 1β含量显著降低（P <0 0 1

P <0 0 5 ）

但与正常组比较无显著性差异（P <0 0 5 ）。模型组大鼠大脑皮层、海马AchE含量较正常组增高

有显著性差异（P <0 0 1）

养寿丹可明显降低模型大鼠皮层及海马中AchE含量

其中高剂量更显著（P <0 0 1）。结论 :提示养寿丹可调控阿尔茨海默病肾阳虚模型大鼠淀粉样前体蛋白基因启动因子IL 1β、AchE在体内的含量

使异常增高降低。

Abstract

Objective To observe the effect of Yang Shou Dan（YSD） on IL-1 β、AchE response elements of APP protein. Methods:Alzheimer’s disease （AD） combining Yang deficiency of Kidney rats model was established by intraperitoneral injection of D-galgctose and intramuscularly injection of prednisolone acetate combined with ibotenic acid injection into bilateral nucleus basalis of Meynert. IL-1 β and AchE were inspected in the brain of rats. Results IL-1 β in model rat was significantly increased compared with the control group （P<0.01）. YSD and Piracetam tablet reduced IL-1 β notably （P<0.01

P<0.05） Compared with the model. However

there was no difference with control group （P>0.05）. AchE in hippocampus and cerebral cortex was elevated in model rat brain （P<0.01）. YSD lowered AchE and the function of high dose was prominence （P<0.01）. Conclusion:It is indicated that YSD can regulate IL-1 β

AchE response elements of APP protein in brain of mdel rat towards the normal levels.

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Related Author

LIU Ming-ping1

HUANG Zhao-sheng1

SUN Wei-guang2

WEI Pin-qing1

LIAO Hui-li3

XUAN Yuan-sheng4

PAN Yanli

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Related Institution

School of Chinese Materia Medica， Beijing University of Chinese Medicine

Institute of Information on Traditional Chinese Medicine，China Academy of Chinese Medical Sciences

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School of Chinese Materia Medica， Guangdong Pharmaceutical University

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