The Effects of Kangxianling Decoction on PDGF-mRNA ,TNFα-mRNA Expression of CRF Rat Renal Tissue

HE Li-qun; WANG Yi; CAO He-xin; LI Jun

doi:10.13422/j.cnki.syfjx.2003.05.014

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The Effects of Kangxianling Decoction on PDGF-mRNA ,TNFα-mRNA Expression of CRF Rat Renal Tissue

更新时间：2024-09-23

- The Effects of Kangxianling Decoction on PDGF-mRNA ,TNFα-mRNA Expression of CRF Rat Renal Tissue
- Chinese Journal of Experimental Traditional Medical Formulae Issue 5, Pages: 29-32(2003)
- 作者机构：
  
  1. 上海中医药大学附属曙光医院肾内科
  2. 上海中医药大学附属曙光医院肾内科上海200021
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2003.05.014
  CLC： R285.5
- Published：2003
- 稿件说明：
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[1]何立群,王怡,曹和欣,李均.抗纤灵冲剂对慢性肾衰模型肾组织TNF-mRNA、PDGF-mRNA的影响[J].中国实验方剂学杂志,2003(05):29-32.

HE Li-qun, WANG Yi, CAO He-xin, et al. The Effects of Kangxianling Decoction on PDGF-mRNA ,TNFα-mRNA Expression of CRF Rat Renal Tissue[J]. Chinese journal of experimental traditional medical formulae, 2003, (5): 29-32.
[1]何立群,王怡,曹和欣,李均.抗纤灵冲剂对慢性肾衰模型肾组织TNF-mRNA、PDGF-mRNA的影响[J].中国实验方剂学杂志,2003(05):29-32. DOI： 10.13422/j.cnki.syfjx.2003.05.014.

HE Li-qun, WANG Yi, CAO He-xin, et al. The Effects of Kangxianling Decoction on PDGF-mRNA ,TNFα-mRNA Expression of CRF Rat Renal Tissue[J]. Chinese journal of experimental traditional medical formulae, 2003, (5): 29-32. DOI： 10.13422/j.cnki.syfjx.2003.05.014.

摘要

目的 :观察抗纤灵冲剂对 5 6肾切除慢性肾衰（CRF）大鼠肾组织肿瘤坏死因子α（TNF α）、血小板源性生长因子（PDGF）的影响。方法 :用RT PCR法检测CRF大鼠肾组织TNFα mRNA及PDGF mRNA表达及应用ELISA法检测实验后各组大鼠血液TNF α含量。结果 :正常组大鼠肾组织仅微弱表达PDGF mRNA、TNFα mRNA

模型大鼠残肾组织有高表达

抗纤灵冲剂有较强的抑制作用

丹参、制大黄作用次之

蒙诺亦有一定的抑制作用。结论 :抗纤灵冲剂通过抑制肾组织TNFα mRNA、PDGF mRNA表达、降低血清TNF α含量

从而减轻了在肾小球和间质ECM的沉积

改善了肾脏纤维化

延缓了肾功能的恶化。

Abstract

Objective:To observe the effect of kangxianling decoction on PDGF-mRNA

TNF α-mRNA expression of CRF Rat renal tissue. Methods:The expression of PDGF-mRNA

TNF α-mRNA level of CRF Rats renal tissue were determined by RT-PCR and the blood TNF-α content of CRF Rats was measured by ELISA method in all groups two months later. Results:There are high expression of PDGF-mRNA

TNF α-mRNA in renal tissue of the model group and there are slightly expression in false operation group. The kangxianling decoction could suppress significantly the expression of PDGF-mRNA

TNF α-mRNA level of CRF Rats renal tissue. The blood TNF-α content of model group was higher than those of the normal group （P<0.01）. The kangxianling decoction could decrease significantly the blood TNF-α content of model group and its effect was better than those of Dan-shen root

Rhubarb and monopril groups （P<0.01）.Conclusion:The kangxianling decoction could relieve the ECM deposition in renal glomerulus and interstitium

improve kidney fibrosis and retard the deterioration of renal function by suppressing the expression of PDGF-mRNA

TNF α-mRNA level of CRF Rat renal tissue

decreasing the blood TNF-α content and the effect of the PDGF

TNF α on cell proliferation of renal tissue.

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Related Author

HE Li-qun

WANG Yi

CAO He-xin

LI Jun

CHEN Yuhang

ZHANG Ye

CHEN Hong

ZHANG Ziwei

Related Institution

Dongfang Hospital， Beijing University of Chinese Medicine

Yunnan Provincial Hospital of Traditional Chinese Medicine

School of Clinical Medicine，Beijing University of Chinese Medicine

Beijing Key Laboratory of Chinese Materia Pharmacology，National Clinical Research Center of Traditional Chinese Medicine for Cardiovascular Diseases，Institute of Basic Medical Sciences， Xiyuan Hospital，China Academy of Chinese Medical Sciences

Natural History Museum of China

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