PENG Li-hua, LIU Shu-zhi, GUO Chun-yan, et al. Skin Penetration Property of Drugs in Two Cataplasma Carriers[J]. Chinese journal of experimental traditional medical formulae, 2005, (5): 1-3.
PENG Li-hua, LIU Shu-zhi, GUO Chun-yan, et al. Skin Penetration Property of Drugs in Two Cataplasma Carriers[J]. Chinese journal of experimental traditional medical formulae, 2005, (5): 1-3. DOI: 10.13422/j.cnki.syfjx.2005.05.001.
Skin Penetration Property of Drugs in Two Cataplasma Carriers
摘要
目的对所制备的中药巴布剂进行透皮吸收实验研究。方法采用改进的透皮扩散试验仪进行经皮渗透实验
经高效液相测定吴茱萸所含吴茱萸碱、吴茱萸次碱在一定时间的经皮累积透过量
并进一步考察两种巴布剂基质的经皮渗透规律。
Abstract
Objectives:To compare the releasing rates in vitro of evodiamine and rutaecarpine in two kinds of cataplasma carriers.Methods:The releasing of evodiamine and rutaecarpine from the cataplasma carriers in vitro were measured
imitating the method of percutaneous absorption by using improved Franz’S diffusion cell and HPLC.Results:The releasing rates of Evodiamine and rutaecarpine in the carrier made of acryl ic resin copotymer and natural copolymers are higher than those in the carrier made of acrylic resin coDolymer and compounded copolymers.And both the releasing processes fit to the Higuchi equation.Conclusion:Both the cataplasma carriers have good drug releasing properties.
Skin Penetration Property of Drugs in Two Cataplasma Carriers
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Related Author
PENG Li-hua
LIU Shu-zhi
GUO Chun-yan
LI Man-ling
FENG Wei-hong
KANG Chen
JIN Ri-xian
BAO Tian-dong
Related Institution
China State Institute of Pharmaceutical Industry
Shanghai Institute of Food and Drug Control
Jilin Agricultural University
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences