Advances in the Animal Models for Non-insulin-dependent Diabetes Mellitus

ZHAO Bao-sheng1; DONG Shu-yun2; HUO Hai-ru1; JIANG Ting-liang1

doi:10.13422/j.cnki.syfjx.2005.05.025

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Advances in the Animal Models for Non-insulin-dependent Diabetes Mellitus

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- Advances in the Animal Models for Non-insulin-dependent Diabetes Mellitus
- Chinese Journal of Experimental Traditional Medical Formulae Issue 5, Pages: 62-66(2005)
- 作者机构：
  
  1.   中国中医研究院中药研究所唐氏研究中心
  2.   河北以岭医院
  3.   中国中医研究院中药研究所唐氏研究中心北京100700
  4.   河北石家庄053400
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2005.05.025
  CLC： R-332
- Published：2005
- 稿件说明：
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[1]赵保胜,董淑云,霍海如,姜廷良.2型糖尿病动物模型的研究进展[J].中国实验方剂学杂志,2005(05):62-66.

ZHAO Bao-sheng1, DONG Shu-yun2, HUO Hai-ru1, et al. Advances in the Animal Models for Non-insulin-dependent Diabetes Mellitus[J]. Chinese journal of experimental traditional medical formulae, 2005, (5): 62-66.
[1]赵保胜,董淑云,霍海如,姜廷良.2型糖尿病动物模型的研究进展[J].中国实验方剂学杂志,2005(05):62-66. DOI： 10.13422/j.cnki.syfjx.2005.05.025.

ZHAO Bao-sheng1, DONG Shu-yun2, HUO Hai-ru1, et al. Advances in the Animal Models for Non-insulin-dependent Diabetes Mellitus[J]. Chinese journal of experimental traditional medical formulae, 2005, (5): 62-66. DOI： 10.13422/j.cnki.syfjx.2005.05.025.

摘要

目的综述近年来2型糖尿病动物模型的几种建立方法。方法主要对2型糖尿病动物模型建立的方法与技术进行综述和评价。结果2型糖尿病动物模型主要可分为自发性2型糖尿病动物模型、实验性2型糖尿病动物模型、基因敲除复制2型糖尿病模型和胰岛素抵抗的细胞模型等四种。结论上述四种动物模型的建立方法各有优缺点

实验性2型糖尿病动物模型价格低廉

可操作性强

并且在一定程度上符合人类糖尿病形成的病理过程

成为目前研究2型糖尿病的最主要动物模型。

Abstract

Objective:To introduce Some establishing methods to Non-insulin-dependent diabetes mellitus（NIDDM） animal model.Methods:The established methods and techniques for the NIDDM animal model are summarized.Results:The NIDDM animal model’s establishing methods can meanly be divided into four aspects:spontaneous NIDDM model

experimental NIDDM model

gene knock-out NIDDM model and anti-insulin cell model for NIDDM.Conclusion:There are advantages and disadvantages in the four aspects to establish the NIDDM animal model.The experimental NIDDM model becomes the most important and commonly used animal model to research NIDDM due to the low-cost

better maneuverability and the similar pathological process with that of human being.

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Related Author

ZHAO Bao-sheng1

DONG Shu-yun2

HUO Hai-ru1

JIANG Ting-liang1

CHEN Yuhang

ZHANG Ye

CHEN Hong

ZHANG Ziwei

Related Institution

Dongfang Hospital， Beijing University of Chinese Medicine

Yunnan Provincial Hospital of Traditional Chinese Medicine

School of Clinical Medicine，Beijing University of Chinese Medicine

Beijing Key Laboratory of Chinese Materia Pharmacology，National Clinical Research Center of Traditional Chinese Medicine for Cardiovascular Diseases，Institute of Basic Medical Sciences， Xiyuan Hospital，China Academy of Chinese Medical Sciences

Natural History Museum of China

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