Objective:To observe gastroenteric hormones content changes of blood in model rat of spleen-qi deficiency during different modelling time points.Methods:Adopting excess fatigue（by swimming） and out of constant diet on rats for constant three weeks and stopping doing on them in the 4w.Results:Compared with the control group

the model rats distinctly appear diet reduction

feces rarefaction

reduction activities

accidie and extrados

etc in modelling 2～3w;weight significantly failed

and it has yet to come back in the 4w;urine D-xylose excretion rate significantly falled during 2～4w;GAS and MTL level of serum failed in the 3w and significantly came back during natural recovery period;SS level markedly lower in the 1w

and no significant changes in the remaining time points;VIP level markedly rised in the 2w

and significantly failed in 3w;SP level clearly failed in the 3w;NPY level clearly lower in the 2～3w

and β-EP level clearly declined in the 4w.Conclusion:The model rat made by excess fatigue and out of constant diet for constant three weeks can appear diet reduction

feces rarefaction

reduction activities

etc;and abnormal changes of weight

urine D-xylose excretion rate

and gastroenteric hormones of Blood.