The Effects of Danggui Buxue Tang on the Erythrocyte Function in the Acute Hypoxic Mice

CHEN Yun-hua~

doi:10.13422/j.cnki.syfjx.2006.10.019

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The Effects of Danggui Buxue Tang on the Erythrocyte Function in the Acute Hypoxic Mice

更新时间：2024-09-23

- The Effects of Danggui Buxue Tang on the Erythrocyte Function in the Acute Hypoxic Mice
- Chinese Journal of Experimental Traditional Medical Formulae Issue 10, Pages: 41-43(2006)
- 作者机构：
  
  1. 北京城市学院
  2. 北京中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2006.10.019
  CLC： R285.5
- Published：2006
- 稿件说明：
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[1]陈云华,孙建宁.当归补血汤对急性缺氧小鼠红细胞功能的影响[J].中国实验方剂学杂志,2006(10):41-43.

CHEN Yun-hua~. The Effects of Danggui Buxue Tang on the Erythrocyte Function in the Acute Hypoxic Mice[J]. Chinese journal of experimental traditional medical formulae, 2006, (10): 41-43.
[1]陈云华,孙建宁.当归补血汤对急性缺氧小鼠红细胞功能的影响[J].中国实验方剂学杂志,2006(10):41-43. DOI： 10.13422/j.cnki.syfjx.2006.10.019.

CHEN Yun-hua~. The Effects of Danggui Buxue Tang on the Erythrocyte Function in the Acute Hypoxic Mice[J]. Chinese journal of experimental traditional medical formulae, 2006, (10): 41-43. DOI： 10.13422/j.cnki.syfjx.2006.10.019.

摘要

目的:研究当归补血汤对急性缺氧小鼠红细胞功能的影响。方法:将小鼠分成五组:正常组

对照组

当归补血汤20

5g/kg组。灌胃给水或药10d后制作急性缺氧模型。然后检测小鼠红细胞膜流动性、红细胞变形性与红细胞免疫功能。结果:当归补血汤5g/kg.d连续10d灌胃给药可预防急性缺氧引起红细胞膜流动性、红细胞变形性及红细胞免疫功能的降低。当归补血汤10g/kg.d

连续10d灌胃给药可对抗急性缺氧引起红细胞膜流动性、红细胞变形性的降低

当归补血汤20g/kg.d对各项指标未观察到明显影响。结论:当归补血汤有增强红细胞功能的作用

可能是该方能补气生血的机理之一。

Abstract

Objective:The effects of Danggui Buxue Tang（Chinese Angelica decoction for replenishing blood;DBT） on the erythrocyte functions were studied in the acute hypoxia mice.Methods:The mice were divided into five groups:control

model

and DBT with three dosages（20

5g/kg·d）.Water or DBT were administrated for 10 days.Acute hypoxia model was made by putting the mice into hermetical specimen bottles for 10 minutes.Then the erythrocyte membrane fluidity

the erythrocyte deformability and the erythrocyte immunity was tested.Results:DBT（5g/kg·d） could prevent the erythrocyte membrane fluidity from decreasing.The same actions were observed for the erythrocyte deformability and the erythrocyte immunity function in the acute hypoxia mice.DBT 10g/kg·d could prevent the erythrocyte membrane fluidity and the erythrocyte deformability from decreasing.However

effects were not observed with DBT 20g/kg.Conclusion:The above study shows that small and middle dose DBT can improve the function of red blood cell

which may be the mechanism of invigorating qi to promote blood of DBT.

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Related Author

CHEN Yun-hua1

SUN Jian-ning2

WANG Ming

XIE Jiarun

LIN Haoyu

CHEN Xi

SUN Jia

Related Institution

School of Traditional Chinese Medicine，Southern Medical University

Zhujiang Hospital of Southern Medical University

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences

Institute of Advanced Medical Sciences, School of Pharmaceutical Sciences, Shandong University

The Second Hospital of Shandong University

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