Objective:To study the preventive and therapeutic effect of Chinese medicine Jiaweibiejiajian Pill（JWBJ）on rats with hepatic fibrosis induced by human serum albumin.Methods:The rats model with hepatic fibrosis was induced by multiple subcutaneous injections of serum albumin solution for 4 times.After it was confirmed that there were albumin antibody in rats serum

and then rats were divided into model-group

low-dose group of JWBJ

mediate-dose group of JWBJ and high-dose group of JWBJ.Rats were given JWBJ orally every day

and injected albumin solution into the rats caudal veins for 9 times during 4 weeks.When hepatic fibrosis was verified to come into being by pathological examination.Alanine amino transaminase（ALT）

aspartate aminotranferase（AST）

total protein（TP）

albumin（ALB） Hyaluronic acid（HA）

Laminin（LN）

Collagen Type（PC） in serum of all rats were examined.Results:Compared with the model group

JWBJ could obviously decrease the concentration of serum ALT

AST

HA

LN

CIV and increase the concentration of serum ALB

TP

and increase the ratio of serum A/G of rats with hepatic fibrosis

and reduce the degree of hepatic fibrosis.Conclusion:JWBJ can effectively prevent and treat hepatic fibrosis induced by serum albumin.