Protective Effects of Gankang on Chemical Liver Injury Induced by D-galactosamine in Mice

WANG Di-sheng~

doi:10.13422/j.cnki.syfjx.2006.10.025

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Protective Effects of Gankang on Chemical Liver Injury Induced by D-galactosamine in Mice

更新时间：2024-09-23

- Protective Effects of Gankang on Chemical Liver Injury Induced by D-galactosamine in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Issue 10, Pages: 58-60(2006)
- 作者机构：
  
  安徽蚌埠医学院第二附属医院,安徽,蚌埠,233040
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2006.10.025
  CLC： R285.5
- Published：2006
- 稿件说明：
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[1]王迪生.甘康冲剂对D-半乳糖胺诱导小鼠化学性肝损伤的保护作用[J].中国实验方剂学杂志,2006(10):58-60.

WANG Di-sheng~. Protective Effects of Gankang on Chemical Liver Injury Induced by D-galactosamine in Mice[J]. Chinese journal of experimental traditional medical formulae, 2006, (10): 58-60.
[1]王迪生.甘康冲剂对D-半乳糖胺诱导小鼠化学性肝损伤的保护作用[J].中国实验方剂学杂志,2006(10):58-60. DOI： 10.13422/j.cnki.syfjx.2006.10.025.

WANG Di-sheng~. Protective Effects of Gankang on Chemical Liver Injury Induced by D-galactosamine in Mice[J]. Chinese journal of experimental traditional medical formulae, 2006, (10): 58-60. DOI： 10.13422/j.cnki.syfjx.2006.10.025.

摘要

目的:探讨甘康冲剂对D-半乳糖胺（D-GalN）致小鼠急性化学性肝损伤的保护作用及可能机制。方法:建立D-GalN诱导小鼠化学性肝损伤模型

分光光度法检测血清中ALT、AST水平和肝匀浆中MDA、NO含量。结果:甘康（200

400和800mg.kg-1）灌胃给药一周均能降低血清中升高的转氨酶水平

使升高的肝脾指数降低;同时发现甘康可降低肝匀浆中升高的MDA和NO水平。结论:甘康颗粒剂对D-GalN致小鼠急性化学性肝损伤具有保护作用

其机制与抗肝细胞氧化等有关。

Abstract

Objective:To investigate the protective effects of Gankang on D-galactosamine-induced liver injury and study its possible mechanism.Methods:The model of chemical injury in liver of mouse was prepared.The level of alanine aminotransferase（ALT）

aspartate aminotransferase（AST） in serum

malondiadehyde（MDA）content

nitric oxide（NO）in liver homogenate were assayed by spectrophotometer.Results:Gankang(200

400

800mg·kg

-1

)significantly decreased the levels of serum transaminase（ALT

AST）

liver index and spleen index.Furthermore

Gankang also decreased MDA and NO level in liver homogenate.Conclusion:Gankang possesses protective action on chemical injury in liver of mice

which is related to its mechanism of ressistance to the liver cell oxidation.

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