Determination of the Content of Baicalin in Xiaoyankangjun Tablets by HPCE

WANG Yang~

doi:10.13422/j.cnki.syfjx.2007.01.004

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Determination of the Content of Baicalin in Xiaoyankangjun Tablets by HPCE

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- Determination of the Content of Baicalin in Xiaoyankangjun Tablets by HPCE
- Chinese Journal of Experimental Traditional Medical Formulae Issue 1, Pages: 8-9(2007)
- 作者机构：
  
  1.   武汉大学人民医院药学部
  2.   武汉大学药学院
  3.   武汉大学人民医院药学部湖北武汉430060
  4.   湖北武汉430072
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2007.01.004
  CLC： R286
- Published：2007
- 稿件说明：
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[1]汪洋,潘细贵,阮晓琪,张洪.高效毛细管电泳法测定消炎抗菌片中黄芩苷含量[J].中国实验方剂学杂志,2007(01):8-9.

WANG Yang~. Determination of the Content of Baicalin in Xiaoyankangjun Tablets by HPCE[J]. Chinese journal of experimental traditional medical formulae, 2007, (1): 8-9.
[1]汪洋,潘细贵,阮晓琪,张洪.高效毛细管电泳法测定消炎抗菌片中黄芩苷含量[J].中国实验方剂学杂志,2007(01):8-9. DOI： 10.13422/j.cnki.syfjx.2007.01.004.

WANG Yang~. Determination of the Content of Baicalin in Xiaoyankangjun Tablets by HPCE[J]. Chinese journal of experimental traditional medical formulae, 2007, (1): 8-9. DOI： 10.13422/j.cnki.syfjx.2007.01.004.

摘要

目的:建立高效毛细管电泳法测定中成药消炎抗菌片中黄芩苷的含量。方法:定量采用内标法

选取苯甲酸钠为内标物。所用毛细管规格为60 cm×75μm（有效长度为45 cm）

检测波长为215 nm

电压为21 kV

电解缓冲液为10 mmol.L-1硼砂

pH为9.0。结果:黄芩苷在96

68μg.mL-1范围内线性关系良好

（r=0.999 7）

加样回收率为98.8%

RSD为1.6%。结论:高效毛细管电泳法用于测定消炎抗菌片中黄芩苷的含量是可行的

本方法简便、快速、准确、重复性好。

Abstract

Objective:To develope a HPCE method for determining the content of baicalin in Xiaoyankangjun Tablets.Methods:Internal standard method was selected as quantitive method and sodium benzoate was used as internal standard.The separation was performed on a fused-silica capillary（60 cm×75 μm

effective length 45 cm）.The detection wavelength was 215 nm and the applied voltage was 21 kV.10 mmol·L

-1

borate（pH 9.0）was used as running buffer;Results:The linear range of the baicalin was 96～768 μg·mL

-1

（r=（0.999 7）） and the recovery was 98.8%（RSD=1.6%）.Conclusions:HPCE is a practicable method in the determination the concentration of baicalin in the Xiaoyankangjun Tablets.

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Related Author

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Related Institution

Research Center for Differentiation and Development of Traditional Chinese Medicine （TCM） Basic Theory， Jiangxi Province Key Laboratory of TCM Etiopathogenisis， Jiangxi University of Chinese Medicine

Henan Academy of Chinese Medicine

The Second Clinical Medical College， Henan University of Chinese Medicine

State Key Laboratory of Functions and Applications of Medicinal Plants，School of Pharmaceutical Sciences，Engineering Center of Microbiology and Biochemical Pharmacy，Experimental Animal Center，Guizhou Medical University

Chengdu University of Traditional Chinese Medicine

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