ZHEN Han-shen, LIANG Jie, ZHOU Fang. Studies on Anti-hyperglycemic Effect of Ethanolic Extracts from Gymnema sylvestre(Retz.)Schult[J]. Chinese journal of experimental traditional medical formulae, 2007, (1): 32-34.
ZHEN Han-shen, LIANG Jie, ZHOU Fang. Studies on Anti-hyperglycemic Effect of Ethanolic Extracts from Gymnema sylvestre(Retz.)Schult[J]. Chinese journal of experimental traditional medical formulae, 2007, (1): 32-34. DOI: 10.13422/j.cnki.syfjx.2007.01.014.
Studies on Anti-hyperglycemic Effect of Ethanolic Extracts from Gymnema sylvestre(Retz.)Schult
Objective:To study the anti-hyperglycemic effect of Gymnema sylvestre(Retz.)Schult 95% Ethanolic Extracts(GSEE).Method:Normal mice
alloxan-induced diabetic mice
adrenaline-induced hyperglycemic mice were used.The anti-hyperglycemic action was studied with radio-immunoassay and glucoseoxidase.Result:High dosage of GSEE could decrease fasted blood sugar in normal mice.It could increase serum insulin level
decrease fasted blood sugar in alloxan-induced diabetic mice.It could also decrease fasted blood sugar in adrenaline-induced hyperglycemic mice.It could improve glucose tolerance in normal mice
and the duration was about 1 hour.Conclusion:GSEE has obvious anti-hyperglycemic effect in alloxan-induced diabetic mice and adrenaline-induced hyperglycemic mice.It could improve glucose tolerance in normal mice.Its mechanism is stimulating of insulin secretion from β cells.
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Related Author
ZHEN Han-shen
LIANG Jie
Zhou Fang
GE Zheng-yan
JIN Long
YAN Ai-guo
DONG Xiao-xia
LI Hong-kun
Related Institution
Hospital of Chengdu University of Traditional Chinese Medicine
First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine
Guizhou Province Natural Medicinal Resources High-Efficacy Application Engineering Center
Key Laboratory of Optimal Utilization of Natural Medicine Resources, Guizhou Medical University
School of Chinese Medicine, Shanxi University of Chinese Medicine