Study Ⅹ on Chemical Substance and Mechanism of Danggui Shaoyao San in the Prevention and Treatment of Senile Dementia——Protective effect of FBD and CO<sub>2</sub> Supercritical Fluid Extract（P<sub>2</sub>） on Astrocyte Anoxic Injury

LIU Jie; LIN Zhi-hong; ZHU Dan-ni; YAN Yong-qing; YU Bo-yang~

doi:10.13422/j.cnki.syfjx.2007.08.008

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Study Ⅹ on Chemical Substance and Mechanism of Danggui Shaoyao San in the Prevention and Treatment of Senile Dementia——Protective effect of FBD and CO₂ Supercritical Fluid Extract（P₂） on Astrocyte Anoxic Injury

更新时间：2024-09-23

- Study Ⅹ on Chemical Substance and Mechanism of Danggui Shaoyao San in the Prevention and Treatment of Senile Dementia——Protective effect of FBD and CO₂ Supercritical Fluid Extract（P₂） on Astrocyte Anoxic Injury
- Chinese Journal of Experimental Traditional Medical Formulae Issue 8, Pages: 14-17(2007)
- 作者机构：
  
  1. 中国药科大学中药复方研究室
  2. 中国药科大学中药复方研究室江苏南京210038
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2007.08.008
  CLC： R285.5
- Published：2007
- 稿件说明：
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[1]刘洁,林志宏,朱丹妮,严永清,余伯阳.当归芍药散防治老年期痴呆的物质基础与作用机理研究Ⅹ——精简方及其CO_2超临界萃取物对星形胶质细胞缺氧损伤的保护作用[J].中国实验方剂学杂志,2007(08):14-17.

LIU Jie, LIN Zhi-hong, ZHU Dan-ni, et al. Study Ⅹ on Chemical Substance and Mechanism of Danggui Shaoyao San in the Prevention and Treatment of Senile Dementia——Protective effect of FBD and CO₂ Supercritical Fluid Extract（P₂） on Astrocyte Anoxic Injury[J]. Chinese journal of experimental traditional medical formulae, 2007, (8): 14-17.
[1]刘洁,林志宏,朱丹妮,严永清,余伯阳.当归芍药散防治老年期痴呆的物质基础与作用机理研究Ⅹ——精简方及其CO_2超临界萃取物对星形胶质细胞缺氧损伤的保护作用[J].中国实验方剂学杂志,2007(08):14-17. DOI： 10.13422/j.cnki.syfjx.2007.08.008.

LIU Jie, LIN Zhi-hong, ZHU Dan-ni, et al. Study Ⅹ on Chemical Substance and Mechanism of Danggui Shaoyao San in the Prevention and Treatment of Senile Dementia——Protective effect of FBD and CO₂ Supercritical Fluid Extract（P₂） on Astrocyte Anoxic Injury[J]. Chinese journal of experimental traditional medical formulae, 2007, (8): 14-17. DOI： 10.13422/j.cnki.syfjx.2007.08.008.

摘要

目的:观察当归芍药散精简方（FBD）及其CO2超临界萃取物（P2）对体外培养的大鼠乳鼠皮质星形胶质细胞缺氧损伤的保护作用。方法:SD大鼠po FBD 125 mg/kg或P216.3 mg/kg后

采集含药脑脊液（CSF-FBD/P2）;MTT法测定FBD、P2人工脑脊液（ACSF-FBD/P2）及其含药脑脊液（CSF-FBD/P2）对Na2S2O4诱导星形胶质细胞缺氧损伤的保护作用。结果:1 mmol/LNa2S2O4作用1 h复氧4 h可显著降低星形胶质细胞活力（P

0.01）;（0.1

）mg/L ACSF-FBD和5%

5%CSF-FBD可显著促进缺氧损伤星形胶质细胞活力（P

0.01）;（0.01

）mg/L ACSF-P2和15%CSF-P2可极显著或显著促进缺氧损伤星形胶质细胞活力（P

0.01

.05）。结论:FBD及其CO2超临界萃取物对星形胶质细胞缺氧损伤具有保护作用。

Abstract

Objective:To observe the protective effect of FBD

the simplified formula from Danggui Shaoyao San（DSS）

and CO

supercritical fluid extract（P\2） on the hypoxic astrocyte anoxic injury.Methods:Sampling cerebrospinal fluid containing FBD/P

（CSF-FBD/P

） after administration with FBD 125 mg/kg or P

16.3 mg/kg;MTT assay was used to measure the viability in the damaged astrocyte induced by Na

.Results:1 h hypoxia and 4 h reoxygen significantly decreased the viability in astrocyte（P

0.01）;（0.1～1）mg/L ACSF-FBD and 5%～15% CSF-FBD can substantially increase the viability of astrocyte induced by Na

（P

0.01）;（0.01～1） mg/L ACSF-P

and 15% CSF-P

can substantially increase the viability of astrocyte（P

0.01～0.05）.Conclusion:FBD and P

could prevent astrocyte from Na

-induced hypoxic damage

which was beneficial to the treatment of cerebral ischemia.

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YU Bo-yang

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LIN Haoyu

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Related Institution

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Study Ⅹ on Chemical Substance and Mechanism of Danggui Shaoyao San in the Prevention and Treatment of Senile Dementia——Protective effect of FBD and CO2 Supercritical Fluid Extract（P2） on Astrocyte Anoxic Injury

DOI：10.13422/j.cnki.syfjx.2007.08.008

摘要

Abstract

关键词

Keywords

references

Study Ⅹ on Chemical Substance and Mechanism of Danggui Shaoyao San in the Prevention and Treatment of Senile Dementia——Protective effect of FBD and CO₂ Supercritical Fluid Extract（P₂） on Astrocyte Anoxic Injury