Effects of Different Extracts of Hongcao from Fufang Hongcao on Acute Myocardial Infarction in Rats

LIU Zhi-bao; LAN Yan-yu~; WANG Yong-lin; WANG Ai-min; LI Yong-jun; HE Xun

doi:10.13422/j.cnki.syfjx.2007.08.010

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Effects of Different Extracts of Hongcao from Fufang Hongcao on Acute Myocardial Infarction in Rats

更新时间：2024-09-23

- Effects of Different Extracts of Hongcao from Fufang Hongcao on Acute Myocardial Infarction in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Issue 8, Pages: 21-24(2007)
- 作者机构：
  
  1. 贵阳医学院
  2. 贵阳医学院贵州贵阳550004
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2007.08.010
  CLC： R285.5
- Published：2007
- 稿件说明：
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[1]刘志宝,兰燕宇,王永林,王爱民,李勇军,何迅.注射用复方荭草中荭草不同工艺提取物对大鼠心肌缺血的影响[J].中国实验方剂学杂志,2007(08):21-24.

LIU Zhi-bao, LAN Yan-yu~, WANG Yong-lin, et al. Effects of Different Extracts of Hongcao from Fufang Hongcao on Acute Myocardial Infarction in Rats[J]. Chinese journal of experimental traditional medical formulae, 2007, (8): 21-24.
[1]刘志宝,兰燕宇,王永林,王爱民,李勇军,何迅.注射用复方荭草中荭草不同工艺提取物对大鼠心肌缺血的影响[J].中国实验方剂学杂志,2007(08):21-24. DOI： 10.13422/j.cnki.syfjx.2007.08.010.

LIU Zhi-bao, LAN Yan-yu~, WANG Yong-lin, et al. Effects of Different Extracts of Hongcao from Fufang Hongcao on Acute Myocardial Infarction in Rats[J]. Chinese journal of experimental traditional medical formulae, 2007, (8): 21-24. DOI： 10.13422/j.cnki.syfjx.2007.08.010.

摘要

目的:经对不同纯化工艺制备的荭草提取物进行药效学比较研究

确定合理可行的精制纯化工艺。方法:采用结扎大鼠冠状动脉左前降支建立急性心肌缺血模型

股静脉给药比较D101大孔吸附树脂吸附分离与正丁醇萃取两种工艺的不同提取部位对急性心肌缺血大鼠心电图、心肌梗死范围、乳酸脱氢酶（LDH）、肌酸激酶（CK）的影响。结果:与大孔吸附树脂比较

荭草的正丁醇提取物能更好地抑制急性心肌缺血大鼠心电图J点升高

减小心肌梗死范围

降低CK、LDH水平。结论:荭草采用正丁醇提取能够将有效成分充分富集。

Abstract

Objective:To compare Pharmacodynamics properties between the extracts of Hongcao

and determine an optimum technique to refine and purify.Methods:The acute myocardial infarction of rat was induced by ligating anterior branch of the left coronary artery.The change of ECG

and the level of CK

LDH were determined

the infarction area of myocardium was also observed.Results:N-butanol extracts of Hongcao could obviously decrease the elevated J of ECG

decrease the infarction area of myocardium

reduce the level of CK

LDH.Conclusion:Adopt n-butanol extraction can concentrate effective composition of Hongcao.

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