Effect of Panax notoginseng（San Qi） and Gynostemma pentaphyllum（Jiao Gu Lan） on Vascular Remodeling in Rabbits

WEN Xiao-Ping~1; ZHENG Xiao-jie~1; Hiroya Kawasaki~2; Takehito Tanbo~2; Masahiko Nonaka~2; CHEN De-xing~

doi:10.13422/j.cnki.syfjx.2007.08.011

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Effect of Panax notoginseng（San Qi） and Gynostemma pentaphyllum（Jiao Gu Lan） on Vascular Remodeling in Rabbits

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- Effect of Panax notoginseng（San Qi） and Gynostemma pentaphyllum（Jiao Gu Lan） on Vascular Remodeling in Rabbits
- Chinese Journal of Experimental Traditional Medical Formulae Issue 8, Pages: 24-28(2007)
- 作者机构：
  
  1. 上海中医药大学
  2. 日本味之素株式会社
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2007.08.011
  CLC： R285.5
- Published：2007
- 稿件说明：
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[1]文小平,郑晓洁,川崎宽也,丹保岳人,野中雅彦,陈德兴.三七、绞股蓝抗兔血管重构的实验研究[J].中国实验方剂学杂志,2007(08):24-28.

WEN Xiao-Ping~1, ZHENG Xiao-jie~1, Hiroya Kawasaki~2, et al. Effect of Panax notoginseng（San Qi） and Gynostemma pentaphyllum（Jiao Gu Lan） on Vascular Remodeling in Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2007, (8): 24-28.
[1]文小平,郑晓洁,川崎宽也,丹保岳人,野中雅彦,陈德兴.三七、绞股蓝抗兔血管重构的实验研究[J].中国实验方剂学杂志,2007(08):24-28. DOI： 10.13422/j.cnki.syfjx.2007.08.011.

WEN Xiao-Ping~1, ZHENG Xiao-jie~1, Hiroya Kawasaki~2, et al. Effect of Panax notoginseng（San Qi） and Gynostemma pentaphyllum（Jiao Gu Lan） on Vascular Remodeling in Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2007, (8): 24-28. DOI： 10.13422/j.cnki.syfjx.2007.08.011.

摘要

目的:研究三七、绞股蓝单方及配伍方对实验性兔动脉粥样硬化（AS）模型血管重构的影响。方法:64只3

月龄新西兰雄兔随机分为正常组（Control）、模型组（Model）、三七组（SQ）、绞股蓝组（JGL）、复方组（FF）、卡托普利组（Captopril）。除正常对照组外

均予耳缘静脉注射牛血清白蛋白250 mg/kg后继喂高脂饲料

同时各药物组给予相应的药物

连续12周。于12周末行胸主动脉HE、EF（弹力纤维）染色

观测VSMC（血管平滑肌细胞）核个数、EF的变化;免疫组织化学标记胸主动脉PCNA（增殖细胞核心抗原）、TGF-β1（转化生长因子-β1）表达。结果:（1）与模型组比较

各药物组主动脉病变不同程度减轻

尤以复方组为优;（2）复方组与模型组比较VSMC核个数显著下降;（3）模型组与正常组比较

主动脉PCNA数密度百分数、TGF-β1面积百分比显著升高（P

0.01）

各药物组有不同程度的降低。结论:三七、绞股蓝及复方通过降低TGF-β1表达

减轻该因子致细胞增殖的作用

减轻血管壁肥厚性重构。

Abstract

Objective:To investigate the effects and mechanisms of Panax notoginseng（SQ） and Gynostemma pentaphyllum（JGL） on vascular remodeling.Methods:A total of sixity-four male New Zealand rabbits was randomly divided into six groups:Normal

Model

JGL

FF（SQ+JGL） and Captopril.The rabbits in control group were fed with regular diet

others were injected with bovine serum albumin 250 mg/kg and fed with high cholesterol diet

meanwhile

durgs were administrated orally.Rabbits were sacrificed at the end of 12 week

aortas serial crosssections were stained with hematoxylin-eosin and elastic fibers.Immunohistochemistry were performed to label PCNA and TGF-β1.Results:（1）The pathological changes of all drug treated groups were alleviated.（2）Compound prescription decreased the quantity of aorta VSMC nucleus compared with model group（P<0.05）.（3）The aorta PCNA immunostaining number and TGF-β1 immunostaining area of model group were significantly higher than normal group（P<0.01）

all drug treated groups decreased.Conclusion:Reduced expression of TGFβ1

and cellular proliferation may be related with inhibition of VR.

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Related Author

WEN Xiao-Ping1

ZHENG Xiao-jie1

Hiroya Kawasaki2

Takehito Tanbo2

Masahiko Nonaka2

CHEN De-xing1

YU Juan

CHEN De-xing

Related Institution

Chengdu University of Traditional Chinese Medicine（TCM）

Hospital of Chengdu University of TCM

Hubei Minzu University

Institute of TCM， Sichuan Academy of Chinese Medicine Sciences

Institute of Traditional Chinese Medicine， Heilongjiang University of Chinese Medicine

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