Effect of Kudzu Extract on Kidney Function of Rats with Diabetes

ZENG Ming~

doi:10.13422/j.cnki.syfjx.2007.08.016

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Effect of Kudzu Extract on Kidney Function of Rats with Diabetes

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- Effect of Kudzu Extract on Kidney Function of Rats with Diabetes
- Chinese Journal of Experimental Traditional Medical Formulae Issue 8, Pages: 42-44(2007)
- 作者机构：
  
  1. 北京军区总医院药理科
  2. 第二军医大学药学院
  3. 第二军医大学海医系
  4. 华东师范大学生命科学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2007.08.016
  CLC： R285.5
- Published：2007
- 稿件说明：
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[1]曾明,郑水庆,陶凯忠,王金萍,边佳明,徐宏发.葛根提取物对糖尿病大鼠肾脏功能的影响[J].中国实验方剂学杂志,2007(08):42-44.

ZENG Ming~. Effect of Kudzu Extract on Kidney Function of Rats with Diabetes[J]. Chinese journal of experimental traditional medical formulae, 2007, (8): 42-44.
[1]曾明,郑水庆,陶凯忠,王金萍,边佳明,徐宏发.葛根提取物对糖尿病大鼠肾脏功能的影响[J].中国实验方剂学杂志,2007(08):42-44. DOI： 10.13422/j.cnki.syfjx.2007.08.016.

ZENG Ming~. Effect of Kudzu Extract on Kidney Function of Rats with Diabetes[J]. Chinese journal of experimental traditional medical formulae, 2007, (8): 42-44. DOI： 10.13422/j.cnki.syfjx.2007.08.016.

摘要

目的:观察葛根提取物对糖尿病大鼠肾功能的影响

探讨其作用机理。方法:采用链脲霉素复制糖尿病肾病大鼠模型

以氨基胍作阳性药物对照

观察葛根提取物对其空腹血糖、血清果糖胺、尿素氮、肌酐

血浆内皮素及6-酮-前列腺素的影响。结果:葛根提取物可降低糖尿病大鼠血糖、血清果糖胺、尿素氮、肌酐、血浆内皮素及6-酮-前列腺素的水平

与模型组相比有显著差异（P<0.01或P<0.05）。结论:葛根提取物具有防治糖尿病大鼠肾病的作用。

Abstract

Objective:To observe the effects of Kudzu extract on kidney function in rats with diabetic nephropathy（DN）

and to probe its mechanism.Methods:The rat model of diabetic nephropathy was induced by streptozotocin.The effects of TFP on diabetic rats were detected by blood sugar before meal

the concentration of fructosamine

urea nitrogen

creatinine in blood serum

and levels of ET

6-keto-PGF

in plasma

compared with aminoguanidin treatment.Results:The Kudzu extract could decrease the level of blood sugar

the concentrations of fructosamine

urea nitrogen

creatinine in blood serum

and levels of ET

6-keto-PGF

in plasma

comparing to that of the diabetic model group（P

0.01

or P

0.05）remarkably.Conclusion:The Kudzu extract has preventive and therapeutic effects on DN.

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XU Hong-fa4

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TAO Kai-zhong3

ZHENG Shui-qing2

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Chun-ling ZHANG

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Related Institution

Key Laboratory of Standardization of Chinese Herbal Medicine，Ministry of Education， College of Pharmacy，Chengdu University of Traditional Chinese Medicine

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