YU Yang, ZHOU Li-ling~, WEI Min, et al. Optimized Preparation of Drug in Adhesive Transdermal Patch by Central Composite Design/Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2007, (9): 14-17.
YU Yang, ZHOU Li-ling~, WEI Min, et al. Optimized Preparation of Drug in Adhesive Transdermal Patch by Central Composite Design/Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2007, (9): 14-17. DOI: 10.13422/j.cnki.syfjx.2007.09.001.
Optimized Preparation of Drug in Adhesive Transdermal Patch by Central Composite Design/Response Surface Methodology
Objective:To optimize the preparation of drug in adhesive transdermal patch.Methods:Taking SD mouse skin as protective screen of the experiment and tackness and transdermal speed constant of vitro as evaluation index to optimize the best matching of plasticizer
cross-linking agent and penetration enhancer in transdermal patch.Results:Second-order quadratic models of index are superior to the plural linear regress equation
plasticizer:cross-linking agent:penetration enhancer is 45%∶2.8%∶7.4%.Conclusions:In this experiment
the established model can describe the relation between factor and index and the outcome of prediction is good.