Study on Fingerprinting of Fu Zhi San

ZHAO Jing-kun~

doi:10.13422/j.cnki.syfjx.2007.11.003

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Study on Fingerprinting of Fu Zhi San

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- Study on Fingerprinting of Fu Zhi San
- Chinese Journal of Experimental Traditional Medical Formulae Issue 11, Pages: 4-7(2007)
- 作者机构：
  
  1. 哈尔滨医科大学附属第一医院
  2. 哈尔滨商业大学药物研究所
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2007.11.003
  CLC： R286
- Published：2007
- 稿件说明：
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[1]赵敬堃,王德生,王建秀,段淑荣,李文兰,白晶.复智散色谱指纹图谱的初步研究[J].中国实验方剂学杂志,2007(11):4-7.

ZHAO Jing-kun~. Study on Fingerprinting of Fu Zhi San[J]. Chinese journal of experimental traditional medical formulae, 2007, (11): 4-7.
[1]赵敬堃,王德生,王建秀,段淑荣,李文兰,白晶.复智散色谱指纹图谱的初步研究[J].中国实验方剂学杂志,2007(11):4-7. DOI： 10.13422/j.cnki.syfjx.2007.11.003.

ZHAO Jing-kun~. Study on Fingerprinting of Fu Zhi San[J]. Chinese journal of experimental traditional medical formulae, 2007, (11): 4-7. DOI： 10.13422/j.cnki.syfjx.2007.11.003.

摘要

目的:建立复智散反相高效液相色谱（RP-HPLC）指纹图谱的分析方法。方法:采用RP-HPLC法

线性梯度洗脱

流动相为乙腈-0.1%磷酸水溶液

体积流量1.0 mL.min-1

检测波长335 nm

柱温30℃。实验测定多批样品并记录指纹图谱

不同样品之间的相似度采用国家药典委员会中药色谱指纹图谱相似度评价系统研究版（2004A）计算。结果:精密度、重复性、稳定性试验中相对共有峰面积和相对保留时间的RSD均小于2%。在选定的色谱条件下确定了19个峰为复智散的指纹特征峰

自制样品平均相似度为0.996。结论:该法精密度高

重复性好

简便实用

可为复智散的指纹图谱评价提供依据。

Abstract

Objective:To establish the chromatographic fingerprints of Fu Zhi San by RP-HPLC.Methods:By RP-HPLC

acetonitrile and water including 0.1% Phosphoric acid were mobile phase with gradient elution

flow rate was 1.0(mL·min

-1

)

the detection wavelength was 335 nm

and the temperature was 30℃.The fingerprints of different samples were compared with similarity evaluation software published by committee codex.Results:The RSD of relative peak areas and relative retention time of common peak in the test of precision

repeatability

and stability has not reached 2%

respectively.19 peaks were identified as the characteristic fingerprints.Average similarity was 0.996.Conclusion:This method is precise

practicable

well-repeated and simple.It can be used as the method to judge the quality of Fu Zhi San.

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Related Institution

Jilin Agricultural University

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences

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