Experimental Study on Function of Decreasing Blood-Lipid in Hyperlipidemia Rats and Safety by Extract of Flos Carthami

YANG Qing; LIANG Ri-xin; YE Jin-xia; WANG Lan; YANG Bin; FU Mei-hong; HUANG Lu-qi

doi:10.13422/j.cnki.syfjx.2007.11.010

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Experimental Study on Function of Decreasing Blood-Lipid in Hyperlipidemia Rats and Safety by Extract of Flos Carthami

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- Experimental Study on Function of Decreasing Blood-Lipid in Hyperlipidemia Rats and Safety by Extract of Flos Carthami
- Chinese Journal of Experimental Traditional Medical Formulae Issue 11, Pages: 30-33(2007)
- 作者机构：
  
  1. 中国中医科学院中药研究所
  2. 中国中医科学院中药研究所北京100700
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2007.11.010
  CLC： R285.5
- Published：2007
- 稿件说明：
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[1]杨庆,梁日欣,叶锦霞,王岚,杨滨,付梅红,黄璐琦.红花提取物对高脂血症模型大鼠降血脂作用和安全性实验研究[J].中国实验方剂学杂志,2007(11):30-33.

YANG Qing, LIANG Ri-xin, YE Jin-xia, et al. Experimental Study on Function of Decreasing Blood-Lipid in Hyperlipidemia Rats and Safety by Extract of Flos Carthami[J]. Chinese journal of experimental traditional medical formulae, 2007, (11): 30-33.
[1]杨庆,梁日欣,叶锦霞,王岚,杨滨,付梅红,黄璐琦.红花提取物对高脂血症模型大鼠降血脂作用和安全性实验研究[J].中国实验方剂学杂志,2007(11):30-33. DOI： 10.13422/j.cnki.syfjx.2007.11.010.

YANG Qing, LIANG Ri-xin, YE Jin-xia, et al. Experimental Study on Function of Decreasing Blood-Lipid in Hyperlipidemia Rats and Safety by Extract of Flos Carthami[J]. Chinese journal of experimental traditional medical formulae, 2007, (11): 30-33. DOI： 10.13422/j.cnki.syfjx.2007.11.010.

摘要

目的:采用大鼠高脂血症模型观察红花提取物降血脂作用

并进行安全性评价。方法:采用高脂饲料喂养大鼠造成高脂血症模型

口服给药1个月后

腹主动脉采血

测定血清甘油三酯（TG）

总胆固醇（TC）

低密度脂蛋白胆固醇（LDL-C）

高密度脂蛋白胆固醇（HDL-C）;小鼠急性毒性实验和大鼠30 d喂养实验。结果:红花水提物明显降低高脂血症大鼠TC

LDL-C;对小鼠最大耐受量大于106.7g生药/kg。大鼠30 d喂养实验

动物无一死亡

无明显中毒症状

各项观察指标不随剂量的增大和受试时间的延长出现剂量反应关系。结论:红花提取物对高脂血症大鼠具有辅助降血脂功能

且无明显的毒性作用。

Abstract

Objective:To observe the function of decreasing blood-lipid by extract from Flos carthami in rat with hyperlipidemia and safety of water extract.Methods:Using hyperlipidemia animal model replicated by hyperlipidemia forage

the levels of TC

HDL

LDL were assayed;actue toxicity test and thirty days feeding study were employed.Results:The levels of TG

LDL-C in all groups treated with the water extract of Flos Carthami were significantly reduced.The alcohol extract of Flos carthami showed a decreased action for TC.For safety

water extract showed no death nor toxic symptom.All the observed index showed no relationship between postponing time and increasing doses during 30 d feeding period.And in teratogenicity tests

pregnant rats grew well;fetuses developed naturally

and the ratio of abnormal fetues was in the range of natural abnormal ratio.Conclusions:The extract of Flos carthami indicaterd the function of decreasing the blood-lipid

and no obvious toxic effects have been observed.

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