Effect and Relevant Mechanism of Jichuanjian on Gastrointestinal Peristalsis in Senile Rat

CHE Yan-zhong~

doi:10.13422/j.cnki.syfjx.2007.11.014

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Effect and Relevant Mechanism of Jichuanjian on Gastrointestinal Peristalsis in Senile Rat

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- Effect and Relevant Mechanism of Jichuanjian on Gastrointestinal Peristalsis in Senile Rat
- Chinese Journal of Experimental Traditional Medical Formulae Issue 11, Pages: 44-46(2007)
- 作者机构：
  
  1. 河南仲景药业股份有限公司
  2. 黑龙江中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2007.11.014
  CLC： R285.5
- Published：2007
- 稿件说明：
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[1]车彦忠,陈洪宝,安立凤,常丽,樊小勇.济川煎对老龄大鼠胃肠蠕动的影响及相关机制研究[J].中国实验方剂学杂志,2007(11):44-46.

CHE Yan-zhong~. Effect and Relevant Mechanism of Jichuanjian on Gastrointestinal Peristalsis in Senile Rat[J]. Chinese journal of experimental traditional medical formulae, 2007, (11): 44-46.
[1]车彦忠,陈洪宝,安立凤,常丽,樊小勇.济川煎对老龄大鼠胃肠蠕动的影响及相关机制研究[J].中国实验方剂学杂志,2007(11):44-46. DOI： 10.13422/j.cnki.syfjx.2007.11.014.

CHE Yan-zhong~. Effect and Relevant Mechanism of Jichuanjian on Gastrointestinal Peristalsis in Senile Rat[J]. Chinese journal of experimental traditional medical formulae, 2007, (11): 44-46. DOI： 10.13422/j.cnki.syfjx.2007.11.014.

摘要

目的:评价济川煎对老龄大鼠胃肠蠕动的影响

并探讨其相关机制。方法:用小肠碳末推进试验观察济川煎对大鼠胃肠蠕动的影响;用放射免疫分析法检测大鼠小肠组织胃动素（MTL）、P物质（SP）和生长抑素（SS）的水平。结果:3.2

4.5 g.kg-1济川煎组大鼠小肠碳末推进率明显高于老龄组（P<0.05

和P<0.01）;3.2

4.5 g.kg-1济川煎组大鼠小肠组织中MTL含量明显高于老龄组（P<0.05）;1.6

3.2 g.kg-1济川煎组大鼠小肠组织中SP含量明显高于老龄组（P<0.01）;1.6

3.2

4.5 g.kg-1济川煎组大鼠小肠组织中SS含量明显低于老龄组（P<0.05

和P<0.01）。结论:济川煎能增强老龄大鼠的胃肠蠕动功能

其机制可能与促进肠道胃动素、P物质的释放

降低肠道生长抑素水平有关。

Abstract

Objective:To investigate the effect of Jichuanjian on gastrointestinal peristalsis of senile rats and study relevant mechanism.Methods:The effect of Jichuanjian on gastrointestinal peristalsis of senile rats was observed by small intestine charcoal powder propelling test.The levels of motilin

substance P and somatostain in small intestine of rats were determinated by radioimmunoassay.Results:Different dosage of Jichuanjian can improve gastrointestinal peristalasis of senile rats and increase the levels of motilin

substance P

with reduce the content of somatostatin in small intestine of senile rats significantly.Conclusions:Jichuanjian can enhance the function of gastrointestinal peristalsis of senile rats by a mechanism of promoting secretion of motilin

substance P and lowering the level of somatostatin in intestine.

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