Pharmacokinetic Study of Loganin in Fructus Corni in Rats

TANG Ji-hui~1; HU Rong-feng~

doi:10.13422/j.cnki.syfjx.2008.01.018

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Pharmacokinetic Study of Loganin in Fructus Corni in Rats

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- Pharmacokinetic Study of Loganin in Fructus Corni in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Issue 1, Pages: 27-29(2008)
- 作者机构：
  
  1. 安徽医科大学
  2. 安徽中医学院
  3. 安徽中医学院第二附属医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2008.01.018
  CLC： R285.5
- Published：2008
- 稿件说明：
移动端阅览
[1]汤继辉,胡容峰,怀素丽.山茱萸中马钱苷大鼠体内药动学研究[J].中国实验方剂学杂志,2008(01):27-29.

TANG Ji-hui~1, HU Rong-feng~. Pharmacokinetic Study of Loganin in Fructus Corni in Rats[J]. Chinese journal of experimental traditional medical formulae, 2008, (1): 27-29.
[1]汤继辉,胡容峰,怀素丽.山茱萸中马钱苷大鼠体内药动学研究[J].中国实验方剂学杂志,2008(01):27-29. DOI： 10.13422/j.cnki.syfjx.2008.01.018.

TANG Ji-hui~1, HU Rong-feng~. Pharmacokinetic Study of Loganin in Fructus Corni in Rats[J]. Chinese journal of experimental traditional medical formulae, 2008, (1): 27-29. DOI： 10.13422/j.cnki.syfjx.2008.01.018.

摘要

目的:建立高效液相色谱法研究山茱萸大鼠灌胃给药后马钱苷的体内药代动力学特点。方法:采用岛津LC-10ATvp高效液相色谱仪

浙江智达N2000工作站

Hypersil C18（4.6 mm×250 mm

5μm）色谱柱

流动相:乙腈-甲醇-0.1%磷酸溶液（10∶5∶85）

流速1.0 mL·min-1

检测波长236 nm

检测山茱萸提取物大鼠灌胃后马钱苷的药代动力学参数。结果:马钱苷的药代动力学模型为单室模型一级吸收

其药代动力学参数为Ka=0.06 min-1

Ke=0.013 min-1

T（peak）=33.90 min

t1/2ka=12.47 min

t1/2ke=52.45 min。结论:高效液相色谱法研究山茱萸大鼠灌胃给药后马钱苷体内药代动力学

方法的专属性强

结果可靠。

Abstract

Objective:To establish a revered phase HPLC method for the study of pharmacokinetics of loganin in Fructus Corni after a single oral administration.Methods:The Hypersil C

（4.6 mm×250 mm

5 μm） was used as the analytical column and the mobile phase consisted of acetonitrile-methanol-0.1% phosphoric acid（10∶5∶85） with the flow rate at 1.0 mL·min

-1

.The UV detection was set at 236 nm.The pharmacokinetic parameters of loganin were recorded.Results:After orally taken Fructus Corni

the plasma concentration-time course in rats fitted well to one-compartment model with the 1’st order absorption and with the following pharmacokinetic parameters:Ka=0.06 min

-1

Ke=0.013 min

T（peak）=33.90 min

1/2ka

=12.47 min

1/2ke

=52.45 min.Conclusions:The HPLC method to determine plasma concentration of loganin and pharamacokinetic parameters in rats is feasible.

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Related Author

TANG Ji-hui1

HU Rong-feng2

HUAI Su-li3

ZHAO Ping1

YAN Run-hong1

LIU Yang-qing1

WANG Yong-hui1

Related Institution

School of Life Sciences，Beijing University of Chinese Medicine

School of Pharmacy，Shanghai University of Traditional Chinese Medicine

School of Graduate Studies，Tianjin University of Traditional Chinese Medicine（TCM）

The Second Affiliated Hospital of Tianjin University of TCM

First Teaching Hospital of Tianjin University of TCM

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