Objective:To study effects of Qingfeixiaoke granule on antitussive

expectorant

antiasthmatic and anti-bacteria

anti-virus

anti-inflammatory.Methods:The following experiments were carried out: cough induced by ammonia

removing phlegm with phenol red

in vivo and in vitro tests for relieving asthma.The effects of the drug on relieving cough

removing phlegm and relieving asthma were investigated;The in-vitro anti-bacteria

and the mouse model infected by pathogenic bacteria

The mouse model of ear edema caused by xylene and the nat midle of tampon granuloma were established to evaluate the anti-bacteria

anti-virus

anti-inflammatory effects.Results:The antitussive expectorant and antiasthmatic experiments of Qingfeixiaoke granule showed that it can restrain mice to cough by ammonia

increase phenol red secretion of mice in bronchus

release asthma induced by histamine phosphate-acetylcholine in guinea pigs

increased latent period of breathe with difficulty and induced asthma.the Anti-bacteria

anti-virus and anti-inflammatory experiments showed that Qingfeixiaoke granule had strong an effect on inhibiting or drowned activity pneumonia streptococcus、α/β-hemolytic streptococcus

staphylococcus aureus and had infirm an effect on inhibiting bacillus coli and bacillus pyocyaneus

the death rate of infected by pneumonia streptococcus in mice could reduce and could prolong the mean survival days.Qingfeixiaoke granule indicated no toxicity to MDCK cells at 12.5 mg·mL

-1

and could effectively inhibit influenza A1 virus at 0.78 mg·mL

-1

could markedly debase indexes of lung of mouse pneumonitis which was elicited by influenza virus;Qingfeixiaoke granule could significantly suppress ear swell induced by xylene in mice and granuloma proliferation.Conclusions:Qingfeixiaoke granule has significant effects on relieving cough

removing phlegm

relieving asthma

also shown effects on anti-bacteria

anti-virus

anti-inflammatory.