XIE Zhong-li~. The Effect of Jiawei Sini Powder on Monoamine Neurotransmitter of Hypothalamus in Rat Chronic Stress Model[J]. Chinese journal of experimental traditional medical formulae, 2008, (1): 50-52.
XIE Zhong-li~. The Effect of Jiawei Sini Powder on Monoamine Neurotransmitter of Hypothalamus in Rat Chronic Stress Model[J]. Chinese journal of experimental traditional medical formulae, 2008, (1): 50-52. DOI: 10.13422/j.cnki.syfjx.2008.01.023.
The Effect of Jiawei Sini Powder on Monoamine Neurotransmitter of Hypothalamus in Rat Chronic Stress Model
Objective:To investigate the effect of Jiawei Sini Powder on monoamine transmitters of Hypothalamus of rat chronic stress model.Methods:Male Sprague-Dauley rats were randomly allocated to five groups as follows:control
model
fluoxetine
Jiawei Sini Powder with small dose and largt dose.The model was produced by sepration and chronic unpredictable mild stress.The behavior was detected by open-field test.HPLC-EC was used to study the changes of monoamine transmitters of Hypothalamus.Results:The results showed that NE level of model group is higher
and 5-HIAA and 5-HT are lower.Fluoxetine and Jiawei Sini Powder decreased the NE level and increased 5-HIAA and 5-HT.Conclusions:The data suggested that dysfanction of monoamine nerve of hypothalamus in rat chronic stress model is related with increased NE and decreased 5-HT
regulation for which may explain the mechanism of Jiawei Sini Powder.
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Related Author
XIE Zhong-li1
LI Jie1
WANG Xing-hua2
GAO Yi
XU Bo
XIA Jing
CHEN Linlin
PANG Zhiwen
Related Institution
Hubei Shizhen Laboratory
Engineering Research Center of Traditional Chinese Medicine Protection Technology and New Product Development for the Elderly Brain Health, Ministry of Education, Hubei University of Chinese Medicine
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Key Laboratory of TCM Viscera Theory and Application, Ministry of Education, Liaoning University of TCM
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