Effect of Glycyrrhiza Uralensis Saponins on Acute Toxicity of Platycodins

WANG Min; LIU Bin; QI Yun; SONG Yang; XIE Chen; LUO Xiu-zhen; CAI Run-lan~

doi:10.13422/j.cnki.syfjx.2008.01.026

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Effect of Glycyrrhiza Uralensis Saponins on Acute Toxicity of Platycodins

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- Effect of Glycyrrhiza Uralensis Saponins on Acute Toxicity of Platycodins
- Chinese Journal of Experimental Traditional Medical Formulae Issue 1, Pages: 59-61(2008)
- 作者机构：
  
  1. 中国医学科学院中国协和医科大学药用植物研究所
  2. 中国医学科学院中国协和医科大学药用植物研究所北京100094
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2008.01.026
  CLC： R285
- Published：2008
- 稿件说明：
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[1]王敏,刘彬,齐云,宋杨,谢忱,罗秀珍,蔡润兰.甘草皂苷对桔梗皂苷急性毒性的影响研究[J].中国实验方剂学杂志,2008(01):59-61.

WANG Min, LIU Bin, QI Yun, et al. Effect of Glycyrrhiza Uralensis Saponins on Acute Toxicity of Platycodins[J]. Chinese journal of experimental traditional medical formulae, 2008, (1): 59-61.
[1]王敏,刘彬,齐云,宋杨,谢忱,罗秀珍,蔡润兰.甘草皂苷对桔梗皂苷急性毒性的影响研究[J].中国实验方剂学杂志,2008(01):59-61. DOI： 10.13422/j.cnki.syfjx.2008.01.026.

WANG Min, LIU Bin, QI Yun, et al. Effect of Glycyrrhiza Uralensis Saponins on Acute Toxicity of Platycodins[J]. Chinese journal of experimental traditional medical formulae, 2008, (1): 59-61. DOI： 10.13422/j.cnki.syfjx.2008.01.026.

摘要

目的:探索中药配伍解毒研究新方法及甘草皂苷对桔梗皂苷毒性的减毒作用。方法:以动物死亡率为评判指标

比较"甘草皂苷干预"及未"甘草皂苷干预"动物的中毒情况。在此基础上

以LD50测定法评估不同剂量甘草皂苷干预的解毒效果。结果:预先给于不同剂量甘草皂苷

可明显降低1 g·kg-1剂量桔梗皂苷致动物死亡率

显著上抬桔梗皂苷LD5095%可信限

延长动物死亡时间。结论:预防性口服给予甘草皂苷可部分缓解口服桔梗皂苷所引起的中毒及死亡。

Abstract

Objective:To explore a new method for the study of compatibility attenuation in TCM

and to investigate the effect of Glycyrrhiza uralensis saponins（GS）on the reduction of the acute toxicity of platycodins.Methods:The death rate of the mice was used to evaluate the acute toxicity induced by platycodins in the condition of pre-treatment with GS and no GS.Furthermore

the attenuation effects of different concentrations of GS were investigated by LD

method.Results:Pre-treatment of different concentrations of GS can reduce obviously the death rate of the mice

elevate the 95% confidence level of the LD

value

prolong the survival time of the mice.Conclusions:Pre-oral administration of GS can partly alleviate the toxicity of platycodins and reduce the death induced by platycodins.

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