Objective:To observe the effect of sesamin on myocardial remodeling in renal hypertensive rats. Methods:The model of two kidneys with one clip （2K1C） of renal hypertensive rat was established

the rats were fed to their stomaches daily for 6 weeks with the different dosages of sesamin. LVWI

NO

ET-1 and HYD were measuered and radioimmunoassay was adopted to determine the levels of endothelin-1 （ET-1） in myocardium

immunohistochemistric assay was utilized to observe the expression of nitric oxide synthase （eNOS） protein of myocardium

the ultramicrostructures of myocardium was observed through electron-microscope. Results:Compared with the sham-operated group

the content of LVWI

HYD and ET-1 were obviously increased

vigor of SOD was drastically decreased

the expression of myocardium eNOS protein was distinctly weakened

and it was indicated that disorder of cardiac muscle fiber and hyperplasia of extracellular collagen fiber through the observation of ultramicrostructure in the 2K1C group. High dosage （100 mg·kg

-1 ） sesamin tangibly ameliorated the pathologic changes such as disorder of cardiac muscle fiber

hyperplasia of extracellular collagen fiber and LVWI

and the content of HYD and ET-1 were obviously decreased

vigor of SOD was drastically increased

the expression of myocardium eNOS protein was clearly increased. Conclusion:The results showed that sesamin has an effect of against myocardial remodeling

its mechanisms were probably mediated through increasing the content of NO

inducing the expression of eNOS protein

decreasing the content of ET-1 and so on.