Objective:To investigate the effect of Qingyi Huaji（QYHJ） Formula on serum immunosuppressive factors and proliferation activity of splenic lymphocytes of mice with pancreatic cancer Panc 02. Methods: The mice were randomly divided into NS group

interleukin-2（IL-2） group and QYHJ groups at low

medium and high dosages. After treatment

tumor growth was evaluated

the levels of serum immunosuppressive factors such as soluble interleukin-2 receptor（sIL-2R）

transforming growth factor β

1

（TGF-β

1

） and vascular endothelial growth factor（VEGF） were measured by ELISA

the proliferation activity of splenic lymphocytes cell were measured by CCK-8 colorimetry. Results: The tumors in all QYHJ groups were lighter than in NS group（P

<

0.05）

the levels of serum sIL-2R

TGF-β

1

and VEGF in all QYHJ groups were lower than in NS group

when the proliferation activity of splenic lymphocytes in all QYHJ groups was higher than in NS group（P

<

0.05）.Conclusion: QYHJ Formula may inhibit the proliferation of pancreatic cancer in vivo

in addition it may inhibit the secretion of immunosuppressive factors and enhance lymphocytes’ immune function so as to improve the immunosuppressive state of the host.