LI Hai-yan~1, LI Xia~1, JIN Xiang-qun~ 1, et al. Effects of Baicalin on the Chronic Alcoholic Liver Injury in Rat[J]. Chinese journal of experimental traditional medical formulae, 2008, (6): 58-60.
LI Hai-yan~1, LI Xia~1, JIN Xiang-qun~ 1, et al. Effects of Baicalin on the Chronic Alcoholic Liver Injury in Rat[J]. Chinese journal of experimental traditional medical formulae, 2008, (6): 58-60. DOI: 10.13422/j.cnki.syfjx.2008.06.023.
Effects of Baicalin on the Chronic Alcoholic Liver Injury in Rat
Objective:To observe the effects of baicalin in chronic alcoholic live injury rats
and to study the terapeutic effects and mechanisms of baicalin on alcoholic live injury rats. Methods:The rats were given 56°(v/v) alcohol 5 mL·kg
-1 twice daily for 28 days by ig
from the 5
th week once daily for 4 weeks.In the same time the rats were given test agents according to the protocol for 28 days. Results: The experiments indicated that baicalin could obviously degraded the content of ALT
AST
MDA in rats’serum and liver and increased the activity of SOD and GSH-Px. It also reduced the content of TNF-α in serum. Conclusions: Baicalin has obvious protective effect to alcoholic liver injury in rats. Down regulation of TNF-α and MDA might be involved in the mechanism.
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Related Author
LI Hai-yan1
LI Xia1
JIN Xiang-qun1
DI Lin2
LIU Xin-yu2
SUN Dan3
CHEN Mengjie
LIU Yimin
Related Institution
Research Center for Differentiation and Development of Traditional Chinese Medicine (TCM) Basic Theory, Jiangxi Province Key Laboratory of TCM Etiopathogenisis, Jiangxi University of Chinese Medicine
Henan Academy of Chinese Medicine
The Second Clinical Medical College, Henan University of Chinese Medicine
First Affiliated Hospital of Guizhou University of TCM
The First Clinical Medical College of Guizhou University of Traditional Chinese Medicine (TCM)