Objective:To study the effect of conjugated linoleic acid magnesium selenium（CMS） on body weight reduction in mice fed by high-fat diet.Methods:63 male Kunming mice were randomly divided into five groups

i.e.normal control group 10

model control group 14

low

middle and high dose groups 13 for each

and fed basal diet for the normal control group

fed high-fat diet for others.At the same time

0.2 mL/10g BW 1.5%CMC+CMS aqueous solution were given orally for three dose groups daily

and 0.2 mL/10 g BW 1.5%CMC aqueous solution for the others.After four weeks

body weight

testis fat were weighed

food consumption and serum TG

HDL

CHO

GIU were measured.Results:The body weight were lower significantly for middle dose group（P<0.05） and high dose group（P<0.01）

testis fat weight and index of testis fat weigh/body weight were lower significantly for three dose groups（P<0.01）

food intake consumption had no obvious change compared with the model control.Conclusions:CMS is effective in lowering body weight and body fat in mice fed by high-fat diet.