Experimental Study on Mechanisms of Cortex Ailanthi in Inhibiting Sarcoma<sub>180</sub> Angiogenesis

GUO Ji-long 1; WANG Shi-jun2

doi:10.13422/j.cnki.syfjx.2008.08.019

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Experimental Study on Mechanisms of Cortex Ailanthi in Inhibiting Sarcoma₁₈₀ Angiogenesis

更新时间：2024-09-23

- Experimental Study on Mechanisms of Cortex Ailanthi in Inhibiting Sarcoma₁₈₀ Angiogenesis
- Chinese Journal of Experimental Traditional Medical Formulae Issue 8, Pages: 48-50(2008)
- 作者机构：
  
  1. 山西中医学院
  2. 山东中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2008.08.019
  CLC： R285.5
- Published：2008
- 稿件说明：
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[1]郭继龙,王世军.椿皮抑制S_(180)肉瘤血管生成机理的实验研究[J].中国实验方剂学杂志,2008(08):48-50.

GUO Ji-long 1, WANG Shi-jun2. Experimental Study on Mechanisms of Cortex Ailanthi in Inhibiting Sarcoma₁₈₀ Angiogenesis[J]. Chinese journal of experimental traditional medical formulae, 2008, (8): 48-50.
[1]郭继龙,王世军.椿皮抑制S_(180)肉瘤血管生成机理的实验研究[J].中国实验方剂学杂志,2008(08):48-50. DOI： 10.13422/j.cnki.syfjx.2008.08.019.

GUO Ji-long 1, WANG Shi-jun2. Experimental Study on Mechanisms of Cortex Ailanthi in Inhibiting Sarcoma₁₈₀ Angiogenesis[J]. Chinese journal of experimental traditional medical formulae, 2008, (8): 48-50. DOI： 10.13422/j.cnki.syfjx.2008.08.019.

摘要

目的:研究收涩中药椿皮抑制血管生成及抗肿瘤生长的作用及机制。方法:采用小鼠移植肿瘤模型

研究椿皮对肿瘤生长的影响;应用免疫组织化学方法

检测肿瘤组织相关第八因子抗原（Ⅷ-RAg）和基质金属蛋白酶9（MMP-9）的表达

通过医用图像处理软件测定肿瘤组织的微血管密度（MVD）。结果:椿皮对小鼠皮下移植肉瘤有明显抑制作用（P<0.05）;血管密度椿皮组明显低于空白和阳性对照组（P<0.05）;椿皮相对于空白对照组MMP-9呈低表达（P<0.05）。结论:收涩中药椿皮对肿瘤血管生成有一定的抑制作用

可以抑制移植S180肉瘤的生长及MMP-9的表达。

Abstract

Objective:To investigate the effect on angiogensis as well as tumor growth for the traditional Chinese medical astringent

such as

Cortex Ailanthi

and the mechanism of the effect.Method:A model of transplanting tumor in mice was used to study the effect of these medical herbs on tumor growth.The expression of Ⅷ-RAg and matrix metalloproteinase-9（MMP-9） in tumor tissue were examined with immunohistochemical method.The microvessel density（MVD） of the tumour tissue was also measured with the Image Pro Plus software.Result:Cortex Ailanthi could obviously inhibit the growth of sarcoma（S

180） transplanted subcutaneously in mice（P

0.05）.There were fewer vessels in sarcoma tissue in Cortex Ailanthi group than in control group and CTX group（P

0.05）.The expression of MMP-9 was lower in Cortex Ailanthi group than in control group（P

0.05）.Conclusion:Cortex Ailanthi can inhibit angiogensis in tumor tissue

and can also suppress the growth of sarcoma（S

180） transplanted in mice and the expression of MMP-9 in the sarcoma tissue.

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Related Author

GUO Ji-long1

WANG Shi-jun2

WEI Yuzhuo

LIU Li

BU Shu

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MIAO Zhiwei

XU Yi

Related Institution

Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine

Affiliated Hospital of Nanjing University of Chinese Medicine

College of Pharmacy，Gansu University of Chinese Medicine

Affiliated Hospital of Gansu University of Chinese Medicine

Clinical College of Traditional Chinese Medicine，Gansu University of Chinese Medicine

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Experimental Study on Mechanisms of Cortex Ailanthi in Inhibiting Sarcoma180 Angiogenesis

DOI：10.13422/j.cnki.syfjx.2008.08.019

摘要

Abstract

关键词

Keywords

references

Experimental Study on Mechanisms of Cortex Ailanthi in Inhibiting Sarcoma₁₈₀ Angiogenesis