Experimental StudyⅠon the Synergia Theory of Processing with Vinegar——Effects of Repetitive Processing with High Dose Vinegar on the Components of Rhizoma Corydalis

YOU Xiu-qi; LI Xian-duan; GU Xue-zhu; MAO Shu-jie~

doi:10.13422/j.cnki.syfjx.2009.02.005

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Experimental StudyⅠon the Synergia Theory of Processing with Vinegar——Effects of Repetitive Processing with High Dose Vinegar on the Components of Rhizoma Corydalis

更新时间：2024-09-23

- Experimental StudyⅠon the Synergia Theory of Processing with Vinegar——Effects of Repetitive Processing with High Dose Vinegar on the Components of Rhizoma Corydalis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 15, Issue 2, Pages: 11-14(2009)
- 作者机构：
  
  中国中医科学院中药研究所
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2009.02.005
  CLC： R283;R284.1
- Published：2009
- 稿件说明：
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[1]游修琪,李先端,顾雪竹,毛淑杰.醋制增效理论实验研究Ⅰ——大剂量醋重复炮制对延胡索成分的影响[J].中国实验方剂学杂志,2009,15(02):11-14.

YOU Xiu-qi, LI Xian-duan, GU Xue-zhu, et al. Experimental StudyⅠon the Synergia Theory of Processing with Vinegar——Effects of Repetitive Processing with High Dose Vinegar on the Components of Rhizoma Corydalis[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(2): 11-14.
[1]游修琪,李先端,顾雪竹,毛淑杰.醋制增效理论实验研究Ⅰ——大剂量醋重复炮制对延胡索成分的影响[J].中国实验方剂学杂志,2009,15(02):11-14. DOI： 10.13422/j.cnki.syfjx.2009.02.005.

YOU Xiu-qi, LI Xian-duan, GU Xue-zhu, et al. Experimental StudyⅠon the Synergia Theory of Processing with Vinegar——Effects of Repetitive Processing with High Dose Vinegar on the Components of Rhizoma Corydalis[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(2): 11-14. DOI： 10.13422/j.cnki.syfjx.2009.02.005.

摘要

目的:研究炮制用醋量及炮制方法对延胡索成分的影响

为阐明醋制入肝增效理论的科学性提供实验依据。方法:制备用醋重复炮制延胡索样品

以HPLC测定延胡索炮制品中延胡索乙素及原阿片碱含量为指标。BDS Hypersil C18柱

流速1.0 mL.min-1

延胡索乙素色谱条件为:甲醇-0.1%磷酸（三乙胺调pH至6.0）（65∶35）为流动相

检测波长280 nm;原阿片碱色谱条件为:乙腈-三乙胺醋酸溶液（每1000 mL水中加入冰醋酸30 mL

三乙胺8 mL）（18∶82）为流动相

检测波长289 nm。结果:100 g延胡索用30 mL醋炮制其有效成分延胡索乙素和原阿片碱溶出量最高

炮制方法以炒法为佳。结论:大剂量醋重复炮制延胡索使成分减少

长时间醋煮法炮制使成分含量下降。

Abstract

Objective:To study the effects of quantity of processing vinegar and processing methods on the components of Rhizoma Corydalis.Methods: HPLC was used to detect the content of tetrahydropalmatine and protopine in processing products of Rhizoma Corydalis.The column was Hypersil BDS（250 mm×4.6 mm

5 μm）

the flow rate was 1.0 mL·min

-1

.For tetrahydropalmatine

mobile phase was methanol-0.1% phosphoric acid（adjust PH 6.0 with triethylamine）（65∶35）

The UV detector was set at 280 nm;For protopine

mobile phase was acetonitrile-triethylamine acetic acid

The UV detector was set at 289 nm.Results: The extraction solubility of tetrahydropalmatine and protopine in Rhizoma Corydalis processed with 30% vinegar（100 g Rhizoma Corydalis with 30 mL vinegar） is the hightest

vinegar-sauted has better effects than vinigar-boiled.Conclusion: The components of Rhizoma Corydalis by repetitive processed with high dose vinegar or boiled in vinegar for long time was decreased.

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YOU Xiu-qi

LI Xian-duan

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MAO Shu-jie

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Related Institution

College of Pharmaceutical Science, Yunnan University of Traditional Chinese Medicine

Henan University of Chinese Medicine

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